HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Barry B.K. Chan Irving L. Kron John A. Kern Charles E. Hobson Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chan, B. B. K. Articles by Tribble, C. G. Search for Related Content PubMed PubMed Citation Articles by Chan, B. B. K. Articles by Tribble, C. G.

Ann Thorac Surg 1993;55:940-945
© 1993 The Society of Thoracic Surgeons

---

Articles

Impairment of vascular endothelial function by high-potassium storage solutions

Department of Surgery, University of Virginia Health Sciences Center, Charlottesville, Virginia USA

Accepted for publication July 23, 1992.

^_* Address reprint requests to Dr Tribble, Department of Surgery, Box 181, University of Virginia Health Sciences Center, Charlottesville, VA 22908.

High-potassium cold storage solutions are currently used to preserve myocardial function during heart transplantation. However, the effects of high potassium concentration on vascular endothelial function are not well known. We therefore tested vascular rings for endothelial-dependent and endolhelial-independent relaxation during storage in nortnokalemic, normothermic buffers and then in buffers supplemented with 10 to 110 mmol/L KCl. Maximal endothelial-dependent relaxation was significantly reduced at all high potassium concentrations. Endolhelial-independent relaxation was impaired only with 80 and 110 mmol/L KCl buffers. Both endothelialdependent relaxation and endothelial-independent relaxation returned to normal values after washout of excess potassium. Similarly, endothelial-dependent relaxation and endothelial-independent relaxation were assessed in rings after 24 hours of hypothermic storage in normokalemic Krebs buffer, and in buffers containing 20 and 110 mmol/L KCl. Maximal endothelial-dependent relaxation was significantly reduced after preservation in the high-potassium solutions, whereas endothelialindependent relaxation was not impaired. We conclude that there is significant impairment of endothelial function after cold storage in a high-potassium buffer. Inadequate washout of potassium during normothermic conditions may lead to further functional impairment of vascular responsiveness. A low-potassium storage medium is recommended for improved vascular protection.

This article has been cited by other articles:

				D. Van Raemdonck and S. Steen Lung preservation Lung Transplantation, July 1, 2010; 86 - 97. [Abstract] [Fulltext] [PDF]

				D. V. Raemdonck, M. Struber, F. Venuta, D. Vlasselaers, W. Wisser, and M. E. Erasmus Strategies in the prevention and the treatment of ischaemia-reperfusion injury after lung transplantation Surgery for Non-Neoplastic Disorders of the Chest: a Clinical Update, June 28, 2010; 66 - 88. [Abstract] [Fulltext] [PDF]

				A. Parolari, P. Rubini, A. Cannata, L. Bonati, F. Alamanni, E. Tremoli, and P. Biglioli Endothelial damage during myocardial preservation and storage Ann. Thorac. Surg., February 1, 2002; 73(2): 682 - 690. [Abstract] [Full Text] [PDF]

				S. Chien, F. Zhang, W. Niu, M. T. Tseng, and L. Gray Jr Comparison of University of Wisconsin, Euro-Collins, low-potassium dextran, And Krebs-Henseleit solutions for hypothermic lung preservation J. Thorac. Cardiovasc. Surg., May 1, 2000; 119(5): 921 - 930. [Abstract] [Full Text] [PDF]

				T. Bando, J. M. Albes, J. Schone, H. Wada, S. Hitomi, T. Wahlers, and H.-J. Schafers Significance of cyclic adenosine monophosphate and nitroglycerin in ET-Kyoto solution for lung preservation Ann. Thorac. Surg., March 1, 2000; 69(3): 887 - 891. [Abstract] [Full Text] [PDF]

				K. Takigami, S. Sasaki, N. Shiiya, M. Kawasaki, E. Takeuchi, and K. Yasuda Evaluation of 18-hour lung preservation with oxygenated blood for optimal oxygen delivery Ann. Thorac. Surg., August 1, 1998; 66(2): 362 - 366. [Abstract] [Full Text] [PDF]

				R. C. King, O. A. R. Binns, R. C. Kanithanon, P. E. Parrino, T. B. Reece, J. D. Maliszewskyj, K. S. Shockey, C. G. Tribble, and I. L. Kron Acellular Low-Potassium Dextran Preserves Pulmonary Function After 48 Hours of Ischemia Ann. Thorac. Surg., September 1, 1997; 64(3): 795 - 800. [Abstract] [Full Text]

				O. A. R. Binns, N. F. DeLima, S. A. Buchanan, J. T. Cope, R. C. King, C. A. Marek, K. S. Shockey, C. G. Tribble, and I. L. Kron BOTH BLOOD AND CRYSTALLOID-BASED EXTRACELLULAR SOLUTIONS ARE SUPERIOR TO INTRACELLULAR SOLUTIONS FOR LUNG PRESERVATION J. Thorac. Cardiovasc. Surg., December 1, 1996; 112(6): 1515 - 1521. [Abstract] [Full Text]

				R. J. Novick, K. E. Gehman, I. S. Ali, and J. Lee Lung Preservation: The Importance of Endothelial and Alveolar Type II Cell Integrity Ann. Thorac. Surg., July 1, 1996; 62(1): 302 - 314. [Abstract] [Full Text]

				G.-W. He and C.-Q. Yang Vascular Tone and Contractility During Exposure to Cardioplegia and Hyperkalemic Solutions Vascular and Endovascular Surgery, July 1, 1995; 29(4): 261 - 272. [Abstract] [PDF]

				K. G. M. Brockbank, M. G. Davies, S. M. Fields, and P.-O. Hagen The Relationship of Human Saphenous Vein Smooth Muscle Contractile Responses to Donor Age and Gender Vascular and Endovascular Surgery, January 1, 1995; 29(1): 15 - 21. [Abstract] [PDF]