HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ali, K. Articles by Furukawa, Y. Search for Related Content PubMed PubMed Citation Articles by Ali, K. Articles by Furukawa, Y.

Ann Thorac Surg 1993;55:902-907
© 1993 The Society of Thoracic Surgeons

---

Articles

Improvement of cardiac function impaired by repeated ischemic arrests in isolated rat hearts

Second Department of Surgery and Department of Pharmacology, Shinshu University School of Medicine, matsumoto, Japan

Accepted for publication July 17, 1992.

^_* Adress reprint to request to Dr Ali, Second Department of Surgery, Shinshu University Schcoi of Medicine, Matsumoto 390, Japan.

We investigated the effects of coenzyme Q₁₀ and verapamil, either alone or in combination, on cardiac function impaired by repeated ischemic arrests and reperfusion in the isolated rat heart. In the group with a single ischemic arrest, the aortic flow, cardiac output, stroke volume, coronary flow, and heart rate recovered well (72% to 100% of the prearrest values). In the repeatedarrest group, the recovery of aortic flow (24%), cardiac output (30%), stroke volume (40%), or coronary flow (63%) was much poorer than that in the single-arrest group. Pretreatment with coenzyme Q₁₀ given intraperitoneally improved aortic flow, cardiac output, stroke volume, coronary flow, and heart rate. The addition of verapamil to the reperfusion solution also protected the cardiac function with a decrease in heart rate. However, combination therapy with coenzyme Q₁₀ and verapamil further increased the recoveries of aortic flow, cardiac output, stroke volume, and coronary flow to 57%, 61%, 77%, and 84%, respectively, which were better than the values after treatment with coenzyme Q₁₀ or verapamil alone. We, therefore, suggest that treatment with coenzyme Q₁₀ or verapamil, alone or in combination, in addition to St. Thomas' Hospital solution effectively protects cardiac function impaired by repeated ischemic arrests and reperfusion.

This article has been cited by other articles:

				D. P. Taggart, M. Jenkins, J. Hooper, L. Hadjinikolas, M. Kemp, D. Hue, and G. Bennett Effects of Short-Term Supplementation With Coenzyme Q10 on Myocardial Protection During Cardiac Operations Ann. Thorac. Surg., March 1, 1996; 61(3): 829 - 833. [Abstract] [Full Text]