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The Annals of Thoracic Surgery, Vol 55, 694-699, Copyright © 1993 by The Society of Thoracic Surgeons
P Garred, E Fosse, MK Fagerhol, V Videm and TE Mollnes
Plasma concentrations of the granulocyte cell marker calprotectin were
assessed during operation and 24 hours postoperatively in patients
undergoing coronary artery bypass grafting with cardiopulmonary bypass,
abdominal aneurysmectomy with implantation of an aortic graft, or
thoracotomy without implantation of synthetic material. The concentration
of calprotectin increased significantly (p < 0.01) in all three groups.
Ten of the 30 patients in the group undergoing cardiopulmonary bypass
received methylprednisolone at the start of the operation. No difference in
calprotectin concentration was seen between the two subgroups (p >
0.05). Plasma concentration of calprotectin was shown to increase rapidly
in patients undergoing cardiopulmonary bypass and aneurysmectomy, in whom
complement activation also took place. However, the calprotectin
concentration increased slowly during the operation and the postoperative
period in patients undergoing a thoracotomy, in whom complement was not
activated. At wound closure the calprotectin concentration was
significantly elevated in the cardiopulmonary bypass and aneurysmectomy
groups compared with the thoracotomy group (p < 0.05). The calprotectin
concentration remained elevated during the postoperative period in all
three groups. Our results indicate that calprotectin may serve as a
suitable cellular marker when the biocompatibility of artificial surfaces
is studied.
ARTICLES
Calprotectin and complement activation during major operations with or without cardiopulmonary bypass
Institute of Immunology and Rheumatology, National Hospital, Oslo, Norway.
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