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Ann Thorac Surg 1993;55:659-661
© 1993 The Society of Thoracic Surgeons

Articles

Topical use of aprotinin in open heart operations

Harun Tatar, MD, Serta[image] [image]i[image]ek, MD*, Ufuk Demirkili[image], MD, Ertugrul Özal, MD, Hikmet Süer, MD, Ömer Öztürk, MD, Hamit Isiklar, MD

Department of Cardiovascular Surgery, GATA, Gulhane School of Medicine, Etlik, Ankara, Turkey

Accepted for publication June 17, 1992.

* Address reprint requests to Dr. Cicek, Cinnah Cad. 53/10, Cankaya, Ankara, 06680, Turkey.

Among various pharmacological agents used to reduce bleeding after open-heart operations, high-dose aprotinin therapy seems most promising. However, its longterm effects are still obscure; there is almost always possibility of bypass graft occlusions produced by the hypercoagulable state induced by aprotinin in coronary bypass operations. Topical application of aprotinin into the pericardial cavity could prevent the adverse effects. Fifty patients were prospectively studied to evaluate the effects of topical aprotinin. One million KIU of aprotinin was poured into the pericardial cavity before closure of the sternotomy in group 1 (n = 25). Patients in group 2 (n = 25) served as controls. Total postoperative bleeding was significantly reduced in group 1 when compared with that of group 2 (722.7 ± 230.8 versus 1,282.6 ±225.7 mL; p < 0.01). The use of banked donor blood products was significantly less in group 1 than in group 2 (0.33 ± 0.67 versus 1.36 ± 0.86 units; p < 0.01). These results show that topical use of aprotinin reduces postoperative blood loss and need for transfusion. It seems promising and warrants further studies to be done.




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