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The Annals of Thoracic Surgery, Vol 55, 502-508, Copyright © 1993 by The Society of Thoracic Surgeons
PS Brown Jr, CS Roberts, CL McIntosh, JA Swain and RE Clark
The purpose of this study was to determine what influence various
combinations of mechanical and bioprosthetic valves in the aortic, mitral,
and tricuspid positions had on late morbidity and mortality of 40 hospital
survivors of triple-valve replacement. At operation the patients ranged in
age from 27 to 69 years; 73% were women. The mean postoperative follow-up
interval was 8.3 years, with a total follow-up of 331 years (100%
complete). At 12 months after operation, functional class decreased from
3.3 to 1.6 (p < 0.05), cardiac index increased from 2.0 to 2.6 L.min-1 x
m-2 (p < 0.05), and pulmonary artery pressures decreased from 59/27 to
40/17 mm Hg (p < 0.05). There were no differences in preoperative
variables between groups. Actuarial survival for the 40 patients (exclusive
of 30-day or in-hospital mortality, which was 31%) was 78% and 74% at 5 and
10 years. At the same milestones, freedom from reoperation was 96% and 54%,
freedom from combined thromboembolism and anticoagulant-related hemorrhage
was 68% and 56%, and freedom from all late valve-related morbidity and
mortality was 64% and 25%. Comparison of the patients with two or more
mechanical prostheses with the patients having two or more bioprostheses
indicated no significant differences in actuarial freedom from late death,
thromboembolic events, or anticoagulant-related hemorrhage. However the
actuarial freedom from reoperation in the groups with two or more
mechanical valves was lower than that of the groups with two or more
bioprosthetic valves (0/10 versus 13/30; p < 0.05).(ABSTRACT TRUNCATED
AT 250 WORDS)
ARTICLES
Late results after triple-valve replacement with various substitute valves
Surgery Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.
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