HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Millner, R. W. Articles by Pepper, J. R. Search for Related Content PubMed PubMed Citation Articles by Millner, R. W. Articles by Pepper, J. R.

The Annals of Thoracic Surgery, Vol 55, 493-501, Copyright © 1993 by The Society of Thoracic Surgeons

ARTICLES

Dynamic cardiomyoplasty in chronic left ventricular failure: an experimental model

RW Millner, M Burrows, I Pearson and JR Pepper
Department of Cardiothoracic Surgery, St. George's Hospital, London, United Kingdom.

Dynamic cardiomyoplasty continues to attract interest as a therapeutic option in the management of heart failure. In a large animal model of ischemic heart failure, we have compared dynamic cardiomyoplasty with both adynamic cardiomyoplasty and a control group. Heart failure was induced by coronary artery ligation in sheep, and under the same anesthetic dynamic cardiomyoplasty (n = 5), adynamic cardiomyoplasty (n = 4), or no further procedure was performed (n = 5). After recovery the animals were housed for a further 3 months. The dynamic cardiomyoplasty underwent a recognized muscle transformation protocol during this period. At terminal studies, the animals were hemodynamically assessed, both under baseline conditions and after colloid volume loading. The data at baseline were compared with unpaired t tests, and the function curves created by volume loading were compared by analysis of variance. Although the changes at baseline were small, there were highly significant improvements in the function curves in the dynamic cardiomyoplasty group when the stimulators were turned on compared with stimulators off (p = 0.005) for cardiac output; p = 0.035 for left ventricular end-diastolic pressure; p = 0.002 for pulmonary artery capillary wedge pressure; p = 0.004 for stroke volume; and p = 0.003 for cardiac power). There were also significant improvements in indices of cardiac performance when the dynamic cardiomyoplasty group was compared with both the control and adynamic cardiomyoplasty groups. We conclude that there is experimental evidence that cardiomyoplasty augments cardiac function in a model of chronic left ventricular failure.

This article has been cited by other articles:

				E. Monnet and J. C. Chachques Animal Models of Heart Failure: What Is New? Ann. Thorac. Surg., April 1, 2005; 79(4): 1445 - 1453. [Abstract] [Full Text] [PDF]

				A.K. Hasnat, E. T. van der Velde, J. K.F. Hon, and M. H. Yacoub Reproducible model of post-infarction left ventricular dysfunction: haemodynamic characterization by conductance catheter Eur. J. Cardiothorac. Surg., July 1, 2003; 24(1): 98 - 104. [Abstract] [Full Text] [PDF]

				R. Krakor, M. Mochalski, T. Kuntze, R. Autschbach, P. Maddaj-Sterba, and F.-W. Mohr Experimental effects of cardiomyoplasty on stressed normal left ventricle in sheep Eur. J. Cardiothorac. Surg., November 1, 1999; 16(5): 506 - 512. [Abstract] [Full Text] [PDF]

				H. J. Patel, D. J. Polidori, J. J. Pilla, T. Plappert, D. Kass, M. S. J. Sutton, E. B. Lankford, and M. A. Acker Stabilization of Chronic Remodeling by Asynchronous Cardiomyoplasty in Dilated Cardiomyopathy : Effects of a Conditioned Muscle Wrap Circulation, November 18, 1997; 96(10): 3665 - 3671. [Abstract] [Full Text]

				L. Aklog, F. Y. Chen, BrianJ. deGuzman, MichaelP. Murphy, WendelJ. Smith, RitaG. Laurence, RobertF. Appleyard, and L. H. Cohn Right Latissimus Dorsi Cardiomyoplasty Improves Left Ventricular Energetics Ann. Thorac. Surg., September 1, 1997; 64(3): 670 - 677. [Abstract] [Full Text]

				H. J. Patel, E. B. Lankford, D. J. Polidori, J. J. Pilla, T. Plappert, M. St. J. Sutton, and M. A. Acker DYNAMIC CARDIOMYOPLASTY: ITS CHRONIC AND ACUTE EFFECTS ON THE FAILING HEART J. Thorac. Cardiovasc. Surg., August 1, 1997; 114(2): 169 - 178. [Abstract] [Full Text]