|
|
||||||||
The Annals of Thoracic Surgery, Vol 55, 441-449, Copyright © 1993 by The Society of Thoracic Surgeons
JS Pirolo, MJ Liptay, EM Brunt, TA Shuman, JL Cox and TB Ferguson Jr
Noninvasive telemetric monitoring of canine heterotopic cardiac allograft
unipolar peak-to-peak amplitude (UPPA) has permitted prospective
surveillance for rejection; moreover, this technique is able to reliably
detect rejection before the development of histologic evidence of myocyte
necrosis. This study was performed to determine whether early cardiac
allograft rejection and the accompanying decline in allograft UPPA were
associated with alterations in regional myocardial blood flow (RMBF). Seven
heterotopic, intrathoracic canine cardiac transplantations were performed
using triple-drug immunosuppression. Native hearts and allografts were
instrumented with right ventricular and left ventricular epicardial
screw-in electrodes connected to subcutaneous telemeters. Daily measurement
of native and graft UPPA was performed; using radioactive microspheres,
native and graft RMBF were determined during the control period and when
UPPA had declined by 15%, 30%, and 45%. Graft histologic status was
determined by endomyocardial biopsy at the time of RMBF determination. Mean
duration of the study was 19.7 +/- 3.9 days. Rejection was documented in
all animals. The UPPA was stable in native hearts; UPPA declined in the
allografts after the onset of rejection. A biphasic change in allograft
blood flow was seen. Initially RMBF increased as UPPA declined; a 30% to
45% reduction in UPPA was associated with a 41% increase in RMBF (p = 0.028
versus allograft control). Subsequently, a significant decline in blood
flow was observed for reductions in UPPA greater than 45% (0.68 +/- 0.44
versus 1.07 +/- 0.47 mL.g-1 x min-1 for a 30% to 45% decline in UPPA; p =
0.007).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Early cardiac allograft rejection is independent of regional myocardial blood flow
Department of Surgery, Barnes Hospital, Washington University School of Medicine, St. Louis, Missouri.
This article has been cited by other articles:
![]() |
J. E. Everett, M. N. Palmer, J. Jessurun, and S. J. Shumway Noninvasive Diagnosis of Cardiac Allograft Rejection in an Orthotopic Canine Model Ann. Thorac. Surg., November 1, 1996; 62(5): 1337 - 1340. [Abstract] [Full Text] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |