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Ann Thorac Surg 1993;55:434-440
© 1993 The Society of Thoracic Surgeons

Articles

Safe pulmonary preservation for 12 hours with low-potassium-dextran solution

Stig Steen, MD, PhD*, Trygve Sjöberg, PhD, Giorgio Massa, MD, Leif Ericsson, MD, Lars Lindberg, MD

Departments of Cardiothoracic Surgery, Pulmonary Medicine, and Anesthesiology and Intensive Care, University Hospital of Lund, Lund, Sweden

Accepted for publication May 27, 1992.

* Address reprint requests to Dr Steen, Department of Cardiothoracic Surgery, University Hospital of Lund, S-221 85 Lund, Sweden.

The function of porcine left lung allografts was studied after perfusion with (150 mL/kg) and storage for 12 hours in a 4 ° to 6 °C low-potassium-dextran solution (Perfadex; Kabi Pharmacia AB, Uppsala, Sweden). After a left lung transplantation, an artificial lung in the form of venoarterial extracorporeal membrane oxygenation was established. The artificial lung has a "biological" heparin-coated surface (Carmeda AB, Stockholm, Sweden), and there is no need for systemic anticoagulation. Immediately thereafter, pneumonectomy of the normal right lung was done. All the animals were weaned from the artificial lung within 1 hour after the pneumonectomy. Six animals were followed up for 24 hours. They were in good condition throughout the 24-hour observation period with arterial oxygen tensions around 200 mm Hg (inspired oxygen fraction = 0.4) and arterial carbon dioxide tensions around 40 mm Hg. This study demonstrates a reliable method for continuous evaluation of the function of a transplanted lung immediately after transplantation and over the ensuing postoperative period. Safe 12-hour lung preservation can be obtained with the low-potassium-dextran solution Perfadex.




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