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Ann Thorac Surg 1993;55:427-433
© 1993 The Society of Thoracic Surgeons

Articles

Autologous vein supported with a biodegradable prosthesis for arterial grafting

Hans-Peter Zweep, MDa,b, Shinichi Satoh, MD, PhDa,b, Berend van der Lei, MD, PhDa,b, Wouter L.J. Hinrichs, PhDa,b, Freerk Dijka,b, Jan Feijen, PhDa,b, Charles R.H. Wildevuur, MD, PhD*,a,b

a Cardiopulmonary Surgery Research Division and Laboratory for Histology and Cell Biology, University Hospital Groningen, Groningen, the Netherlands
b Department of Biomaterials, University Twente, Enschede, the Netherlands

Accepted for publication May 21, 1992.

* Address reprint requests to Dr Wildevuur, Cardiopulmonary Surgery Research Division, University Hospital Groningen, Oostersingel 59, 9713 EZ Groningen, the Netherlands.

To evaluate the potential of a supporting, compliant, biodegradable prosthesis to function as a temporary protective scaffold for autologous vein grafts in the arterial circulation, we implanted vein grafts into the carotid arteries of rabbits, either with (composite grafts) or without (control grafts) such a supporting prosthesis, and evaluated them up to 6 weeks. The control vein grafts showed edema and severe medial disruption with infiltration of polymorphonuclear cells on day 1. Over the study, irregular fibrocyte formation resulted in the formation of a fibrotic vein wall. In contrast, the composite vein grafts showed preservation of smooth muscle cell layers and elastic laminae with a minor inflammatory response. Regular proliferation of fibroblasts, which in some areas were circularly oriented, was observed. We conclude that a supporting, compliant, biodegradable prosthesis can function as a protective scaffold for vein grafts in the arterial circulation, thus reducing damage to the vein graft wall and allowing gradual arterialization.




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