| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1993;55:420-426
© 1993 The Society of Thoracic Surgeons
Departments of Cardiothoracic Surgery and Anatomical Pathology, Medical School, University of the Orange Free State, Bloemfontein, Republic of South Africa
Accepted for publication May 19, 1992.
* Address reprint requests to Dr Neethling, Department of Cardio-thoracic Surgery, Admin Building, Rm 8, National Hospital, Bloemfontein, 9301, Republic of South Africa.
We investigated changes in myocardial pH during cardioplegic arrest with five methods of preservation at 15 ° ± 1 °C. Twenty-five dogs were subjected to cardiopulmonary bypass for 150 minutes. Group I (control) had hypothermia only. Group II received THAM-buffered blood cardioplegia, group III a bicarbonate-buffered blood cardioplegic solution, group IV infusions of hyperkalemic blood, and group V oxygenated St. Thomas 2 solution. After 120 minutes of ischemia, interstitial pH in group I was markedly depressed (6.4 ± 0.07; p < 0.01). The pH in groups II and IV was well maintained (7.23 ± 0.05 and 7.27 ± 0.07) and differed significantly (p < 0.05) from that of the remaining groups. The pH in groups III and V was less well maintained (7.14 ± 0.02 and 7.01 ± 0.05), with no significant difference (p > 0.05) between these two groups. Postreperfusion functional recovery after 45 minutes was 24% ± 6% in group I, 92% ± 3% in group II, 82% ± 5% in group III, 84% ± 4% in group IV, and 66% ± 6% in group V. Creatine kinase levels were significantly (p < 0.01) increased and ultrastructural damage was more prominent in group I compared with the remaining groups. Myocardial water content significantly increased in all groups. We conclude that a strongly buffered blood-based cardioplegic solution is more effective in preventing interstitial acidosis during moderate hypothermia and that maintenance of an optimal tissue pH plays an important role in postischemic functional recovery.
This article has been cited by other articles:
|
|
 |
|
  K. M. D'Souza, N. N. Petrashevskaya, W. H. Merrill, and S. A. Akhter Inhibition of protein kinase C{alpha} improves myocardial -adrenergic receptor signaling and ventricular function in a model of myocardial preservation J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 172 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Curro, G. Bombardieri, C. Barilaro, P. Di Francesco, C. Varano, G. Possati, and C. Pragliola Time Dependence of Endothelium-Mediated Vasodilation by Intermittent Antegrade Warm Blood Cardioplegia Ann. Thorac. Surg., November 1, 1997; 64(5): 1354 - 1359. [Abstract] [Full Text]
|
|
|
|
|
|
P. Menasche Blood Cardioplegia: Do We Still Need to Dilute? Ann. Thorac. Surg., October 1, 1996; 62(4): 957 - 960. [Full Text]
|
|
|
|
|
|
J. C. Cleveland Jr, D. R. Meldrum, R. T. Rowland, A. Banerjee, and A. H. Harken Optimal Myocardial Preservation: Cooling, Cardioplegia, and Conditioning Ann. Thorac. Surg., February 1, 1996; 61(2): 760 - 768. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Fonger, Y. Zhou, H. Matsuura, G. S. Aldea, and R. J. Shemin Enhanced preservation of acutely ischemic myocardium with transseptal left ventricular assist Ann. Thorac. Surg., March 1, 1994; 57(3): 570 - 575. [Abstract] [PDF]
|
|
|
|
|
|
X. Liu, R. M. Engelman, Z. Wei, N. Maulik, J. A. Rousou, J. E. Flack III, D. W. Deaton, and D. K. Das Postischemic deterioration of sarcoplasmic reticulum: Warm versus cold blood cardioplegia Ann. Thorac. Surg., November 1, 1993; 56(5): 1154 - 1159. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
