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Rémi Houel
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Ann Thorac Surg 1993;55:310-313
© 1993 The Society of Thoracic Surgeons

Articles

Pharmacological bridge to cardiac transplantation: Current limitations

Daniel Y. Loisance, MD*, Philippe H. Deleuze, MD, Rémi Houel, MD, Christophe Benvenuti, MD, Adel El Sayed, MD, Jean-Philippe Mazzucotelli, MD, Antoine Tarral, MD, Jean-Pierre Saal, MD, Jean-Paul Cachera, MD

Centre de Recherches Chirurgicales, Service de Chirurgie Cardiaque, and Service de Cardiologie, CHU Henri Mondor, Faculté de Medicine, Creteil, France

* Address reprint requests to Dr Loisance, Centre de Recherches Chirurgicales, CHU Henri Mondor, Faculté de Médecine, 8, rue du Général Sarrail 94000 Creteil, France.

Addition of intravenous enoximone to sympathomimetic agents permits a rapid and drastic improvement in the clinical and hemodynamical condition of patients in cardiogenic shock referred for a mechanical bridge to transplantation. The present experience, based on the management of 52 patients, permits us to point out the current limitations of this pharmacological bridge: the rate of sudden death, the incompleteness of the physical rehabilitation of the patients, and the vanishing effect of intravenous enoximone.




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