HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Farrar, D. J. Articles by Hill, J. D. Search for Related Content PubMed PubMed Citation Articles by Farrar, D. J. Articles by Hill, J. D.

The Annals of Thoracic Surgery, Vol 55, 276-282, Copyright © 1993 by The Society of Thoracic Surgeons

ARTICLES

Univentricular and biventricular Thoratec VAD support as a bridge to transplantation

DJ Farrar and JD Hill
Department of Cardiovascular Surgery, California Pacific Medical Center, San Francisco 94120.

As of October 1991, the Thoratec ventricular assist device (VAD) system has been used in 154 transplant candidates who were in imminent risk of dying before donor heart procurement at 39 medical centers in 10 countries. The VAD system consists of a prosthetic ventricle with a 65- mL pumping chamber made from Thoratec's BPS-215M polyurethane, cannulas for atrial or ventricular inflow and arterial outflow connections, and a pneumatic drive console. The devices can be used for partial or complete support of the pulmonary, systemic, or both circulations. In all patients (average age, 42 years; range, 11 to 64 years), the pumps were placed in a paracorporeal position on the anterior abdominal wall and connected to the heart and great vessels by cannulas crossing the chest wall. Biventricular support was used in 120 patients (78%) and isolated left VADs were used in 34. Average flow rate was 5.0 +/- 0.9 L/min for the left VAD and 4.3 +/- 0.8 L/min for the right VAD. The most frequent complications were bleeding (42% incidence, 7% mortality) and infection (36% incidence, 8% mortality). Ninety-eight patients (65%) recovered sufficiently to undergo heart transplantation after 8 hours to 226 days of support (average, 17.5 days), and 3 are waiting on VADs for transplantation. Eighty-two patients who received transplants have been discharged. This is an 84% early post-transplantation survival and a 54% overall survival. The actuarial survival 1 year after transplantation is 82%, comparable with that of conventional heart transplantation.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				E. C. McGee Jr., P. M. McCarthy, and N. Moazami Temporary Mechanical Circulatory Support Card. Surg. Adult, January 1, 2008; 3(2008): 507 - 534. [Full Text]

				S. J. Stachelek, I. Alferiev, J. M. Connolly, M. Sacks, R. P. Hebbel, R. Bianco, and R. J. Levy Cholesterol-Modified Polyurethane Valve Cusps Demonstrate Blood Outgrowth Endothelial Cell Adhesion Post-Seeding In Vitro and In Vivo Ann. Thorac. Surg., January 1, 2006; 81(1): 47 - 55. [Abstract] [Full Text] [PDF]

				L. E. Samuels, E. C. Holmes, P. Garwood, and F. Ferdinand Initial Experience With the Abiomed AB5000 Ventricular Assist Device System Ann. Thorac. Surg., July 1, 2005; 80(1): 309 - 312. [Abstract] [Full Text] [PDF]

				S. Salzberg, M. Lachat, G. Zund, E. Oechslin, E.R. Schmid, M. DeBakey, and M. Turina Left ventricular assist device as bridge to heart transplantation - lessons learned with the MicroMed DeBakey axial blood flow pump Eur. J. Cardiothorac. Surg., July 1, 2003; 24(1): 113 - 118. [Abstract] [Full Text] [PDF]

				L. W. Miller Patient selection for the use of ventricular assist devices as a bridge to transplantation Ann. Thorac. Surg., June 1, 2003; 75(90060): S66 - 71. [Abstract] [Full Text] [PDF]

				N. Moazami and P. M. McCarthy Temporary Circulatory Support Card. Surg. Adult, January 1, 2003; 2(2003): 495 - 520. [Full Text]

				H. Luckraz, M. Woods, and S. R. Large And hemolysis goes on: ventricular assist device in combination with veno-venous hemofiltration Ann. Thorac. Surg., February 1, 2002; 73(2): 546 - 548. [Abstract] [Full Text] [PDF]

				O.H. Frazier, T. J. Myers, R. K. Jarvik, S. Westaby, D. W. Pigott, I. D. Gregoric, T. Khan, D. W. Tamez, J. L. Conger, and M. P. Macris Research and development of an implantable, axial-flow left ventricular assist device: the Jarvik 2000 Heart Ann. Thorac. Surg., March 1, 2001; 71 (2007): S125 - S132. [Abstract] [Full Text] [PDF]

				R. Korfer, A. El-Banayosy, L. Arusoglu, K. Minami, M. M. Korner, L. Kizner, O. Fey, U. Schutt, M. Morshuis, and H. Posival SINGLE-CENTER EXPERIENCE WITH THE THORATEC VENTRICULAR ASSIST DEVICE J. Thorac. Cardiovasc. Surg., March 1, 2000; 119(3): 596 - 600. [Abstract] [Full Text] [PDF]

				M. T. Swartz, G. A. Lowdermilk, D. A. Moroney, and L. R. McBride Ventricular assist device support in patients with mechanical heart valves Ann. Thorac. Surg., December 1, 1999; 68(6): 2248 - 2251. [Abstract] [Full Text] [PDF]

				R. Korfer, A. El-Banayosy, L. Arusoglu, K. Minami, T. Breymann, D. Seifert, and L. Kizner Temporary pulsatile ventricular assist devices and biventricular assist devices Ann. Thorac. Surg., August 1, 1999; 68(2): 678 - 683. [Abstract] [Full Text] [PDF]

				D. Mavroidis, B. C. Sun, and W. E. Pae Jr Bridge to transplantation: the Penn State experience Ann. Thorac. Surg., August 1, 1999; 68(2): 684 - 687. [Abstract] [Full Text] [PDF]

				S. A. Hunt and O.H. Frazier Mechanical Circulatory Support and Cardiac Transplantation Circulation, May 26, 1998; 97(20): 2079 - 2090. [Full Text] [PDF]

				J. P. Slater, E. A. Rose, H. R. Levin, O. H. Frazier, J. K. Roberts, A. D. Weinberg, and M. C. Oz Low Thromboembolic Risk Without Anticoagulation Using Advanced-Design Left Ventricular Assist Devices Ann. Thorac. Surg., November 1, 1996; 62(5): 1321 - 1327. [Abstract] [Full Text]

				R. G. Masters, P. J. Hendry, R. A. Davies, S. Smith, C. Struthers, V. M. Walley, J. P. Veinot, T. V. Mussivand, and W. J. Keon Cardiac Transplantation After Mechanical Circulatory Support: A Canadian Perspective Ann. Thorac. Surg., June 1, 1996; 61(6): 1734 - 1739. [Abstract] [Full Text]

				PaulJ. Hendry, H. Nathan, K. Rajagopalan, and BEng Right Ventricular Blood Flow During Left Ventricular Support in an Experimental Porcine Model Ann. Thorac. Surg., April 1, 1996; 61(4): 1199 - 1204. [Abstract] [Full Text]

				A. El-Banayosy, H. Posival, K. Minami, L. Arusoglu, L. Kizner, T. Breymann, D. Seifert, M. Korner, H. Kortke, O. Fey, et al. Mechanical circulatory support: lessons from a single centre Perfusion, March 1, 1996; 11(2): 93 - 102. [Abstract] [PDF]

				D. D. Muehrcke, P. M. McCarthy, R. W. Stewart, R. C. Foster, D. A. Ogella, J. A. Borsh, and D. M. Cosgrove III Extracorporeal Membrane Oxygenation for Postcardiotomy Cardiogenic Shock Ann. Thorac. Surg., February 1, 1996; 61(2): 684 - 691. [Abstract] [Full Text]

				R. Korfer, A. El-Banayosy, H. Posival, K. Minami, L. Kizner, L. Arusoglu, and M. M. Korner Mechanical Circulatory Support With the Thoratec Assist Device in Patients With Postcardiotomy Cardiogenic Shock Ann. Thorac. Surg., January 1, 1996; 61(1): 314 - 316. [Abstract] [Full Text]