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Ann Thorac Surg 1993;55:159-161
© 1993 The Society of Thoracic Surgeons

Articles

Combined thrombolytic therapy for prosthetic mitral valve thrombosis

Charles M.T. Jost, MDa,b, Clyde W. Yancy, Jr, MD*,a,b, W. Steves Ring, MDa,b

a Division of Cardiology, Department of Internal Medicine, Division of Cardiothoracic Surgery, Department of Surgery Dallas, Texas USA
b The Harry S. Moss Heart Center, the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas USA

Accepted for publication April 9, 1992.

* Address reprint requests to Dr Yancy, Cardiology Division, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235-9034.

Prosthetic valve thrombosis is associated with high mortality. The treatment of choice remains operation. This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk. Combined thrombolytic therapy or therapy with a single agent with a long half-life and a prolonged infusion time is suggested as an emergent treatment option for prosthetic mitral valve thrombosis.




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R. Roudaut, S. t. Lafitte, M.-F. Roudaut, C. Courtault, J.-M. Perron, C. Jais, X. Pillois, P. Coste, and A. DeMaria
Fibrinolysis of mechanical prosthetic valve thrombosis: A single-center study of 127 cases
J. Am. Coll. Cardiol., February 19, 2003; 41(4): 653 - 658.
[Abstract] [Full Text] [PDF]


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