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The Annals of Thoracic Surgery, Vol 55, 159-161, Copyright © 1993 by The Society of Thoracic Surgeons

ARTICLES

Combined thrombolytic therapy for prosthetic mitral valve thrombosis

CM Jost, CW Yancy Jr and WS Ring
Department of Internal Medicine, UT Southwestern Medical Center, Dallas 75235-9034.

Prosthetic valve thrombosis is associated with high mortality. The treatment of choice remains operation. This is a case report of the successful combination therapy of tissue plasminogen activator and urokinase for an isolated thrombosed prosthetic mitral valve in a postpartum patient in whom operation was thought to carry an unacceptable risk. Combined thrombolytic therapy or therapy with a single agent with a long half-life and a prolonged infusion time is suggested as an emergent treatment option for prosthetic mitral valve thrombosis.


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R. Roudaut, S. t. Lafitte, M.-F. Roudaut, C. Courtault, J.-M. Perron, C. Jais, X. Pillois, P. Coste, and A. DeMaria
Fibrinolysis of mechanical prosthetic valve thrombosis: A single-center study of 127 cases
J. Am. Coll. Cardiol., February 19, 2003; 41(4): 653 - 658.
[Abstract] [Full Text] [PDF]


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Copyright © 1993 by The Society of Thoracic Surgeons.