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The Annals of Thoracic Surgery, Vol 54, 1236-1243, Copyright © 1992 by The Society of Thoracic Surgeons
SW Downing and LH Edmunds Jr
Cardiopulmonary bypass is associated with bleeding and thrombotic
complications, massive fluid shifts, and cellular and hormonal defense
reactions that are collectively termed "the whole body inflammatory
response." A host of vasoactive substances are produced, released or
altered during cardiopulmonary bypass. These hormones, autacoids, and
cytokines react with specific receptor proteins distributed throughout the
body, and mediate the vascular smooth muscle and endothelial cell
contractions that are responsible for much of the morbidity associated with
open heart operations. This essay briefly reviews the actions, sources, and
perturbations of the approximately 25 vasoactive substances known or
believed to be altered by cardiopulmonary bypass, and provides an
introductory reference list.
ARTICLES
Release of vasoactive substances during cardiopulmonary bypass
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia.
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P. Mathieu, J. Dupuis, M. Carrier, P. Cernacek, M. Pellerin, L. P. Perrault, R. Cartier, J. Taillefer, and L. C. Pelletier Pulmonary metabolism of endothelin 1 during on-pump and beating heart coronary artery bypass operations J. Thorac. Cardiovasc. Surg., June 1, 2001; 121(6): 1137 - 1142. [Abstract] [Full Text] [PDF]
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Y. Hayashi, Y. Sawa, M. Nishimura, S. J. Tojo, N. Fukuyama, H. Nakazawa, and H. Matsuda P-selectin participates in cardiopulmonary bypass-induced inflammatory response in association with nitric oxide and peroxynitrite production J. Thorac. Cardiovasc. Surg., September 1, 2000; 120(3): 558 - 565. [Abstract] [Full Text] [PDF]
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E. A. Grossi, K. Kallenbach, S. Chau, C. C. Derivaux, M. G. Aguinaga, B. M. Steinberg, D. Kim, S. Iyer, M. Tayyarah, M. Artman, et al. Impact of heparin bonding on pediatric cardiopulmonary bypass: a prospective randomized study Ann. Thorac. Surg., July 1, 2000; 70(1): 191 - 196. [Abstract] [Full Text] [PDF]
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