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The Annals of Thoracic Surgery, Vol 54, 1206-1208, Copyright © 1992 by The Society of Thoracic Surgeons
RC Shamberger, ME Wohl, A Perez-Atayde and WH Hendren
The case of a boy with hyperimmunoglobulin E syndrome or Job's syndrome is
presented to demonstrate the occurrence of pneumatoceles in this syndrome
as well as their unusual natural history and failure to spontaneously
resolve. Surgical resection was required for two complications in this
patient, persistent bronchopleural fistula and a pulmonary abscess that
destroyed one lung and required pneumonectomy. Pathologic examination of
the specimens demonstrated the wall of the cysts consisted of granulation
tissue with chronic active inflammation surrounded by infarcted pulmonary
parenchyma with coagulative necrosis. The mechanism responsible for
increased immunoglobulin E production in this syndrome is unknown, as is
the manner in which elevated immunoglobulin E levels impair normal immune
function.
ARTICLES
Pneumatocele complicating hyperimmunoglobulin E syndrome (Job's Syndrome)
Department of Surgery, Children's Hospital, Boston, Massachusetts 02115.
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R. A. Hall, K. E. Salhany, E. Lebel, J. E. Bavaria, and L. R. Kaiser Fungal Pulmonary Abscess in an Adult Secondary to Hyperimmunoglobulin E (Job's) Syndrome Ann. Thorac. Surg., March 1, 1995; 59(3): 759 - 761. [Abstract] [Full Text] |
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