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The Annals of Thoracic Surgery, Vol 54, 1206-1208, Copyright © 1992 by The Society of Thoracic Surgeons

ARTICLES

Pneumatocele complicating hyperimmunoglobulin E syndrome (Job's Syndrome)

RC Shamberger, ME Wohl, A Perez-Atayde and WH Hendren
Department of Surgery, Children's Hospital, Boston, Massachusetts 02115.

The case of a boy with hyperimmunoglobulin E syndrome or Job's syndrome is presented to demonstrate the occurrence of pneumatoceles in this syndrome as well as their unusual natural history and failure to spontaneously resolve. Surgical resection was required for two complications in this patient, persistent bronchopleural fistula and a pulmonary abscess that destroyed one lung and required pneumonectomy. Pathologic examination of the specimens demonstrated the wall of the cysts consisted of granulation tissue with chronic active inflammation surrounded by infarcted pulmonary parenchyma with coagulative necrosis. The mechanism responsible for increased immunoglobulin E production in this syndrome is unknown, as is the manner in which elevated immunoglobulin E levels impair normal immune function.

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				H M A de Bie, L van Toledo-Eppinga, J I M L Verbeke, and R M van Elburg Neonatal pneumatocele as a complication of nasal continuous positive airway pressure Arch. Dis. Child. Fetal Neonatal Ed., May 1, 2002; 86(3): F202 - F203. [Abstract] [Full Text] [PDF]

				R. A. Hall, K. E. Salhany, E. Lebel, J. E. Bavaria, and L. R. Kaiser Fungal Pulmonary Abscess in an Adult Secondary to Hyperimmunoglobulin E (Job's) Syndrome Ann. Thorac. Surg., March 1, 1995; 59(3): 759 - 761. [Abstract] [Full Text]