ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Cyril Serrick
Hani Shennib
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adoumie, R.
Right arrow Articles by Shennib, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adoumie, R.
Right arrow Articles by Shennib, H.

Ann Thorac Surg 1992;54:1071-1077
© 1992 The Society of Thoracic Surgeons


Articles

Early cellular events in the lung allograft

Riad Adoumie, MD, Cyril Serrick, BS, Adel Giaid, PhD, Hani Shennib, MD*

The Joint Marseille-Montreal Lung Transplant Program, Montreal, Quebec, Canada

* Address reprint requests to Dr Shennib, The Joint Marseille-Montreal Lung Transplant Program, Montreal General Hospital, 1650 Cedar Ave, Montreal, Que, Canada H3G 1A4.

We hypothesized that ischemic insult to the lung allograft may render it more susceptible to rejection. Left canine single-lung allografts were subjected to usual periods of cold and warm ischemia (4 hours and 1 hour, respectively). Bronchoalveolar lavage and open lung biopsies were performed at 0,1, 4, and 24 hours and 1 week after transplantation. Bronchoalveolar lavage fluid was examined for cellular phenotypes, lymphocyte lectin-mediated cytotoxicity, and natural killer cell cytotoxicity. Open lung biopsy specimens were examined for severity of injury/rejection and MHC class II expression. Within 1 to 4 hours of reimplantation, we observed marked influx of polymorphonuclear leukocytes and lymphocytes and an increase in lectin-mediated cytotoxicity (25.6% ± 14.8% and 50.6% ± 20.1% versus 5.4% ±7.5% preoperatively; (p < 0.05). In addition, natural killer cell cytotoxicity increased from 10.2% ± 13.5% before transplantation to 20.5% ± 8.6% 4 hours after transplantation (p < 0.03). By 24 hours MHC class II expression became evident and continued to increase while subtle histologic evidence of rejection appeared by 1 week. We conclude that ischemia-reperfusion injury can alter the local bronchopulmonary milieu, thus rendering it more susceptible to the development of rejection.




This article has been cited by other articles:


Home page
Cardiovasc ResHome page
S. F. Rodrigues and D. N. Granger
Role of blood cells in ischaemia-reperfusion induced endothelial barrier failure
Cardiovasc Res, July 15, 2010; 87(2): 291 - 299.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Zhao, L. G. Fernandez, A. Doctor, A. K. Sharma, A. Zarbock, C. G. Tribble, I. L. Kron, and V. E. Laubach
Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury
Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L1018 - L1026.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
M. de Perrot, M. Liu, T. K. Waddell, and S. Keshavjee
Ischemia-Reperfusion-induced Lung Injury
Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 490 - 511.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
K. NOWAK, M. KAMLER, M. BOCK, J. MOTSCH, S. HAGL, H. JAKOB, and M.-M. GEBHARD
Bronchial Artery Revascularization Affects Graft Recovery after Lung Transplantation
Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 216 - 220.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
K. C. MEYER, D. R. NUNLEY, J. H. DAUBER, A. T. IACONO, R. J. KEENAN, R. D. CORNWELL, and R. B. LOVE
Neutrophils, Unopposed Neutrophil Elastase, and Alpha1-Antiprotease Defenses Following Human Lung Transplantation
Am. J. Respir. Crit. Care Med., July 1, 2001; 164(1): 97 - 102.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
H. Itano, M. Aoe, S. Ichiba, M. Yamashita, H. Date, A. Andou, and N. Shimizu
Partial liquid ventilation for acute allograft dysfunction after canine lung transplantation
Ann. Thorac. Surg., February 1, 1999; 67(2): 332 - 339.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
A. K. Qayumi, M. Nikbakht-Sangari, D. V. Godin, J. C. English, K. J. Horley, P. A. Keown, S. P. Lim, D. M. Ansley, and M. S. Koehle
The relationship of ischemia-reperfusion injury of transplanted lung and the up-regulation of major histocompatibility complex II on host peripheral
J. Thorac. Cardiovasc. Surg., May 1, 1998; 115(5): 978 - 982.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
H. Reichenspurner, R. E. Girgis, R. C. Robbins, J. V. Conte, R. V. Nair, V. Valentine, G. J. Berry, R. E. Morris, J. Theodore, and B. A. Reitz
Obliterative bronchiolitis after lung and heart-lung transplantation
Ann. Thorac. Surg., December 1, 1995; 60(6): 1845 - 1853.
[Abstract] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
T. Shiraishi, S. R. DeMeester, N. K. Worrall, J. H. Ritter, T. P. Misko, T. B. Ferguson Jr., J. D. Cooper, and G. A. Patterson
INHIBITION OF INDUCIBLE NITRIC OXIDE SYNTHASE AMELIORATES RAT LUNG ALLOGRAFT REJECTION
J. Thorac. Cardiovasc. Surg., November 1, 1995; 110(5): 1449 - 1460.
[Abstract] [Full Text]


Home page
Ann. Thorac. Surg.Home page
T. Shiraishi, T. Mizuta, S. R. DeMeester, J. H. Ritter, P. E. Swanson, M. R. Wick, J. D. Cooper, and G. A. Patterson
Effect of ischemic injury on subsequent rat lung allograft rejection
Ann. Thorac. Surg., October 1, 1995; 60(4): 947 - 951.
[Abstract] [PDF]


Home page
Ann. Thorac. Surg.Home page
K. Uthoff, K. J. Zehr, P. C. Lee, R. A. Low, W. A. Baumgartner, D. E. Cameron, and R. Scott Stuart
Neutrophil modulation results in improved pulmonary function after 12 and 24 hours of preservation
Ann. Thorac. Surg., January 1, 1995; 59(1): 7 - 13.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1992 by The Society of Thoracic Surgeons.