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Uberto Bortolotti
Paolo Ius
Gaetano Thiene
Aldo Milano
Carlo Valfrè
Alessandro Mazzucco
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Ann Thorac Surg 1992;54:952-957
© 1992 The Society of Thoracic Surgeons

Articles

The meadox-gabbay pericardial xenograft: Failure of the unicusp principle

Uberto Bortolotti, MD*,a,b, Paolo Ius, MDa,b, Gaetano Thiene, MDa,b, Marco Minarini, BSa,b, Aldo Milano, MDa,b, Carlo Valfrè, MDa,b, Enrico Talenti, MDa,b, Marialuisa Valente, MDa,b, Alessandro Mazzucco, MDa,b

a Departments of Cardiovascular Surgery, Pathology, and Radiology, University of Padova Medical School, Padova, Italy
b Department of Cardiovascular Surgery, Treviso Regional Hospital, Treviso, Italy

Accepted for publication March 30, 1992.

* Address reprint requests to Dr Bortolotti, Istituto di Chirurgia Cardiovascolare, Centro di Cardiochirurgia "V. Gallucci," Università di Padova, Via Giustiniani, 2, 35128 Padova, Italy.

Durability of a new bioprosthesis, the Meadox-Gabbay unileaflet pericardial xenograft, was evaluated by reviewing a series of 12 patients who received this device in the mitral position from 1983 to 1985. Bioprosthetic failure necessitated reoperation in 5 patients 21, 22, 53, 66, and 81 months after placement. Three patients died of cardiac failure after 31, 52, and 70 months; no postmortem examinations were done. In 2 of the 3 patients, an echocardiographic study had shown signs of valvular dysfunction. Pathological examination of five available explants revealed the presence of redundancy and stretching of the single pericardial leaflet in all of them; in one, this lesion alone caused severe prosthetic incompetence. Other pathological findings included cusp and commissural calcification and commissural tears with or without calcification. Histologic examination and electron microscopy showed intrinsic calcification involving both collagen bundles and cellular debris and various degrees of collagen disruption. In this limited series of patients, the Meadox-Gabbay pericardial xenograft demonstrated various modes of failure that markedly impair its durability and render it unsuitable as a cardiac valve substitute.






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Copyright © 1992 by The Society of Thoracic Surgeons.