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Ann Thorac Surg 1992;54:898-901
© 1992 The Society of Thoracic Surgeons

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Articles

Role of open lung biopsy in diagnosing pulmonary complications of AIDS

Division of Cardiothoracic Surgery, George Washington University Medical Center, Washington, DC, USA

Accepted for publication March 2, 1992.

^_* Address reprint requests to Dr Hix, Division of Cardiothoracic Surgery, George Washington University, 2150 Pennsylvania Ave, NW, Washington, DC 20037.

Over a 4-year period, 25 patients with pulmonary complications of acquired immunodeficiency syndrome underwent open lung biopsy for diagnosis. Results of the biopsy led to a change in therapy in 15, and of this group, 8 patients improved clinically and were discharged. We believe that a select group of acquired immunodeficiency syndrome patients with pulmonary disease will benefit from open lung biopsy. Our indications for open lung biopsy are (1) a nondiagnostic bronchoscopy, (2) failed medical therapy after a diagnostic bronchoscopy, (3) failed empiric medical therapy after a nondiagnostic bronchoscopy or after a second nondiagnostic bronchoscopy, and (4) when any of the forementioned are accompanied with a worsening chest roentgenogram. Patients with acquired immunodeficiency syndrome who have a deteriorating respiratory status or require mechanical ventilation should not undergo open lung biopsy.

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