ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mezrow, C. K.
Right arrow Articles by Griepp, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mezrow, C. K.
Right arrow Articles by Griepp, R. B.

The Annals of Thoracic Surgery, Vol 54, 609-615, Copyright © 1992 by The Society of Thoracic Surgeons


ARTICLES

Cerebral blood flow and metabolism in hypothermic circulatory arrest

CK Mezrow, AM Sadeghi, A Gandsas, HH Shiang, D Levy, R Green, IR Holzman and RB Griepp
Department of Cardiothoracic Surgery, Mount Siani Medical Center, New York, NY 10029.

Although hypothermic circulatory arrest has been accepted for use in cardiovascular operations, the potential for cerebral injury exists. The mechanism of the cerebral injury remains unclear. To address these questions we studied cerebral blood flow and metabolism. Sixteen puppies were randomly assigned to undergo either 45 or 90 minutes of hypothermic circulatory arrest after perfusion/surface cooling to 13 degrees C. Cerebral blood flow, cerebral oxygen and glucose metabolism, and cerebral vascular resistance measurements were obtained at 37 degrees C, 13 degrees C, 10 minutes after reperfusion, 30 degrees C and 2 and 4 hours after hypothermic circulatory arrest. No neurologic or behavioral changes were observed in any of the long-term survivors (11/16). Metabolic and cerebral blood flow data did not differ between groups. Cerebral blood flow was significantly lower in the late postarrest measurements, whereas oxygen and glucose consumption had returned to baseline values. In the presence of low cerebral blood flow and high cerebral vascular resistance it is notable that control levels of oxygen consumption were attained by abnormally high oxygen extraction. These data strongly suggest a vulnerable interval after hypothermic circulatory arrest in which cerebral metabolism is limited by cerebral blood flow.


This article has been cited by other articles:


Home page
J Intensive Care MedHome page
M. H. Trujillo, E. Bellorin-Font, C. F. Fragachan, and R. Perret-Gentil
Multiple Organ Failure Following Near-fatal Exertional Heat Stroke
J Intensive Care Med, January 1, 2009; 24(1): 72 - 78.
[Abstract] [PDF]


Home page
Ann. Thorac. Surg.Home page
F. Bakhtiary, S. Dogan, A. Zierer, O. Dzemali, F. Oezaslan, P. Therapidis, F. Detho, T. Wittlinger, S. Martens, P. Kleine, et al.
Antegrade Cerebral Perfusion for Acute Type A Aortic Dissection in 120 Consecutive Patients
Ann. Thorac. Surg., February 1, 2008; 85(2): 465 - 469.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
E. Hickey, T. Karamlou, X. You, C. Komanapalli, T. Person, K. Wehrley, and R. Ungerleider
The Use of a Miniaturized Circuit and Bloodless Prime To Avoid Cerebral No-Reflow After Neonatal Cardiopulmonary Bypass
Ann. Thorac. Surg., March 1, 2007; 83(3): 895 - 901.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
J. T. Strauch, D. Spielvogel, A. Lauten, N. Zhang, S. Rinke, D. Weisz, C. A. Bodian, and R. B. Griepp
Optimal temperature for selective cerebral perfusion
J. Thorac. Cardiovasc. Surg., July 1, 2005; 130(1): 74 - 82.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
J. T. Strauch, D. Spielvogel, P. L. Haldenwang, A. Lauten, N. Zhang, D. Weisz, C. A. Bodian, and R. B. Griepp
Cerebral physiology and outcome after hypothermic circulatory arrest followed by selective cerebral perfusion
Ann. Thorac. Surg., December 1, 2003; 76(6): 1972 - 1981.
[Abstract] [Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
J. T. Strauch, D. Spielvogel, P. L. Haldenwang, N. Zhang, D. Weisz, C. A. Bodian, and R. B. Griepp
Impact of hypothermic selective cerebral perfusion compared with hypothermic cardiopulmonary bypass on cerebral hemodynamics and metabolism
Eur. J. Cardiothorac. Surg., November 1, 2003; 24(5): 807 - 816.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
R. B. Griepp
Cerebral protection during aortic arch surgery
J. Thorac. Cardiovasc. Surg., March 1, 2003; 125(90030): S36 - 38.
[Full Text] [PDF]


Home page
Card Surg AdultHome page
D. Spielvogel, M. N. Mathur, and R. B. Griepp
Aneurysms of the Aortic Arch
Card. Surg. Adult, January 1, 2003; 2(2003): 1149 - 1168.
[Full Text]


Home page
NEJMHome page
The Hypothermia after Cardiac Arrest Study Group
Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest
N. Engl. J. Med., February 21, 2002; 346(8): 549 - 556.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
M. P. Ehrlich, J. N. McCullough, N. Zhang, D. J. Weisz, T. Juvonen, C. A. Bodian, and R. B. Griepp
Effect of hypothermia on cerebral blood flow and metabolism in the pig
Ann. Thorac. Surg., January 1, 2002; 73(1): 191 - 197.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
M. P. Ehrlich, J. McCullough, D. Wolfe, N. Zhang, H. Shiang, D. Weisz, C. Bodian, and R. B. Griepp
Cerebral effects of cold reperfusion after hypothermic circulatory arrest
J. Thorac. Cardiovasc. Surg., May 1, 2001; 121(5): 923 - 931.
[Abstract] [Full Text] [PDF]


Home page
J. Thorac. Cardiovasc. Surg.Home page
R. B. Griepp
Cerebral protection during aortic arch surgery
J. Thorac. Cardiovasc. Surg., March 1, 2001; 121(3): 425 - 427.
[Full Text] [PDF]


Home page
Eur. J. Cardiothorac. Surg.Home page
S. M. Langley, P. J. Chai, J. J. Jaggers, and R. M. Ungerleider
Preoperative high dose methylprednisolone attenuates the cerebral response to deep hypothermic circulatory arrest
Eur. J. Cardiothorac. Surg., March 1, 2000; 17(3): 279 - 286.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
S. M. Langley, P. J. Chai, S. E. Miller, J. R. Mault, J. J. Jaggers, S. S. Tsui, A. J. Lodge, A. Lefurgey, and R. M. Ungerleider
Intermittent perfusion protects the brain during deep hypothermic circulatory arrest
Ann. Thorac. Surg., July 1, 1999; 68(1): 4 - 12.
[Abstract] [Full Text] [PDF]


Home page
Ann. Thorac. Surg.Home page
T. Higami, S. Kozawa, T. Asada, H. Obo, K. Gan, K. Iwahashi, and H. Nohara
Retrograde cerebral perfusion versus selective cerebral perfusion as evaluated by cerebral oxygen saturation during aortic arch reconstruction
Ann. Thorac. Surg., April 1, 1999; 67(4): 1091 - 1096.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
P. M. Kirshbom, L. A. Skaryak, L. R. DiBernardo, F. H. Kern, W. J. Greeley, J. W. Gaynor, and R. M. Ungerleider
Effects of Aortopulmonary Collaterals on Cerebral Cooling and Cerebral Metabolic Recovery After Circulatory Arrest
Circulation, November 1, 1995; 92(9): 490 - 494.
[Abstract] [Full Text]


Home page
J. Thorac. Cardiovasc. Surg.Home page
C. L. Filgueiras, B. Winsborrow, J. Ye, J. Scott, A. Aronov, P. Kozlowski, L. Shabnavard, R. Summers, J. K. Saunders, R. Deslauriers, et al.
A 31P-magnetic resonance study of antegrade and retrograde cerebral perfusion during aortic arch surgery in pigs
J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 55 - 62.
[Abstract] [Full Text]


Home page
J. Thorac. Cardiovasc. Surg.Home page
N. Yoshimura, M. Okada, T. Ota, and H. Nohara
Pharmacologic intervention for ischemic brain edema after retrograde cerebral perfusion
J. Thorac. Cardiovasc. Surg., June 1, 1995; 109(6): 1173 - 1181.
[Abstract] [Full Text]


Home page
Ann. Thorac. Surg.Home page
H. J. Safi, D. C. Iliopoulos, S. P. Gopinath, K. R. Hess, P. J. Asimacopoulos, S. Bartoli, S. A. Raskin, Ccp, A. T. Shaibani, C. M. Leveque, et al.
Retrograde Cerebral Perfusion During Profound Hypothermia and Circulatory Arrest in Pigs
Ann. Thorac. Surg., May 1, 1995; 59(5): 1107 - 1112.
[Abstract] [Full Text]


Home page
Ann. Thorac. Surg.Home page
J. van der Linden
Cerebral Hemodynamics After Low-Flow Versus No-Flow Procedures
Ann. Thorac. Surg., May 1, 1995; 59(5): 1321 - 1325.
[Abstract] [Full Text]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1992 by The Society of Thoracic Surgeons.