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Ann Thorac Surg 1992;54:552-554
© 1992 The Society of Thoracic Surgeons

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Articles

Cardiac valve replacement in patients infected with the human immunodeficiency virus

Infectious Diseases Section, Medical Service, and Cardiothoracic Surgery Section, Surgical Service, Department of Veterans Affairs Medical Center, New York, New York USA

Accepted for publication December 4, 1991.

^_* Address reprint requests to Dr Bräu, Infectious Diseases Section, Department of Veterans Affairs Medical Center, 423 East 23rd St, New York, NY 10010.

Major surgical procedures, especially when performed under general anesthesia, can depress immunological parameters measured in vitro. Therefore concern has been expressed that operation might have an adverse effect on the immune status of individuals infected with the human immunodeficiency virus (HIV). Four HIV-positive patients without symptoms of HIV disease underwent cardiac valve replacement in consequence of infective endocarditis. After up to 15 months postoperalively, 3 patients are alive and well without signs of progressive immunodeficiency or recurrent endocarditis. One patient died of recurrent endocarditis without evidence of HIV-related disease on autopsy. Cardiac operation does not seem to accelerate HIV-related immunodeficiency.

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