| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1992;54:460-466
© 1992 The Society of Thoracic Surgeons
Division of Thoracic Surgery, Memorial Sloan-Kettering Cancer Center and Cornell University Medical College, New York, New York USA
* Address reprint requests to Dr Martini, 1275 York Ave, New York, NY 10021.
From 1973 to 1989, 214 patients with stage II non-small cell lung cancer were treated by resection and complete mediastinal lymph node dissection. There were 116 adenocarcinomas and 98 squamous cancers. There were 35 T1 N1 and 179 T2 N1 tumors. Whereas T1 tumors were mainly adenocarcinomas (83%), this difference was not apparent in T2 lesions. Regardless of histology, half of the patients had a single involved N1 lymph node. Lobectomy was performed in 68% of the patients, pneumonectomy in 31%, and wedge resection or segmentectomy in 1%. Lobectomy was sufficient to encompass all disease in 34 of 35 T1 N1 tumors. Only 48 patients (22%) received postoperative external irradiation and 11 patients (5%) received chemotherapy. The overall 5-year disease-free survival was 39%. The best survival rates were in patients who had a single node involved and tumors 3 cm or less in diameter (48%). The pattern of recurrence differed by histology. Local or regional recurrence was more frequent in patients with squamous carcinoma whereas distant metastases were more commonly seen in adenocarcinomas (87%) with brain as the most frequent site (adenocarcinoma, 52%; squamous, 34%). It is concluded that in stage II carcinomas, resection remains the treatment of choice, that mediastinal lymph node dissection provides the most accurate staging, and that the best adjuvant treatment to improve survival is yet to be determined.
This article has been cited by other articles:
|
|
 |
|
  R. Maeda, J. Yoshida, G. Ishii, T. Hishida, M. Nishimura, and K. Nagai Risk Factors for Tumor Recurrence in Patients With Early-Stage (Stage I and II) Non-small Cell Lung Cancer: Patient Selection Criteria for Adjuvant Chemotherapy According to the Seventh Edition TNM Classification Chest, December 1, 2011; 140(6): 1494 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jonnalagadda, C. Smith, G. Mhango, and J. P. Wisnivesky The Number of Lymph Node Metastases as a Prognostic Factor in Patients With N1 Non-small Cell Lung Cancer Chest, August 1, 2011; 140(2): 433 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shimada, M. Tsuboi, H. Saji, K. Miyajima, J. Usuda, O. Uchida, N. Kajiwara, T. Ohira, T. Hirano, H. Kato, et al. The Prognostic Impact of Main Bronchial Lymph Node Involvement in Non-Small Cell Lung Carcinoma: Suggestions for a Modification of the Staging System Ann. Thorac. Surg., November 1, 2009; 88(5): 1583 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Kassis, A. A. Vaporciyan, S. G. Swisher, A. M. Correa, B. N. Bekele, J. J. Erasmus, W. L. Hofstetter, R. Komaki, R. J. Mehran, C. A. Moran, et al. Application of the revised lung cancer staging system (IASLC Staging Project) to a cancer center population J. Thorac. Cardiovasc. Surg., August 1, 2009; 138(2): 412 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Demir, A. Turna, C. Kocaturk, M. Z. Gunluoglu, U. Aydogmus, N. Urer, M. A. Bedirhan, A. Gurses, and S. I. Dincer Prognostic Significance of Surgical-Pathologic N1 Lymph Node Involvement in Non-Small Cell Lung Cancer Ann. Thorac. Surg., April 1, 2009; 87(4): 1014 - 1022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Whitson, S. S. Groth, S. J. Duval, S. J. Swanson, and M. A. Maddaus Surgery for Early-Stage Non-Small Cell Lung Cancer: A Systematic Review of the Video-Assisted Thoracoscopic Surgery Versus Thoracotomy Approaches to Lobectomy Ann. Thorac. Surg., December 1, 2008; 86(6): 2008 - 2018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Poncelet, J. Cornet, C. Coulon, P. Collard, P. Noirhomme, B. Weynand, and groupe d'oncologie thoracique des Cliniques Saint- Intra-tumoral vascular or perineural invasion as prognostic factors for long-term survival in early stage non-small cell lung carcinoma Eur J Cardiothorac Surg, May 1, 2008; 33(5): 799 - 804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Fukai, Y. Sakao, M. Sakuraba, S. Oh, K. Shiomi, S. Sonobe, Y. Saitoh, and H. Miyamoto The prognostic value of carcinoembryonic antigen in T1N1M0 and T2N1M0 non-small cell carcinoma of the lung Eur J Cardiothorac Surg, September 1, 2007; 32(3): 440 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fujimoto, S. D. Cassivi, P. Yang, S. A. Barnes, F. C. Nichols, C. Deschamps, M. S. Allen, and P. C. Pairolero Completely resected N1 non-small cell lung cancer: Factors affecting recurrence and long-term survival. J. Thorac. Cardiovasc. Surg., September 1, 2006; 132(3): 499 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Okamoto, R. Maruyama, R. Suemitsu, Y. Aoki, H. Wataya, M. Kojo, and Y. Ichinose Prognostic value of the histological subtype in completely resected non-small cell lung cancer Interact CardioVasc Thorac Surg, August 1, 2006; 5(4): 362 - 366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Meyers, F. Haddad, B. A. Siegel, J. B. Zoole, R. J. Battafarano, N. Veeramachaneni, J. D. Cooper, and G. A. Patterson Cost-effectiveness of routine mediastinoscopy in computed tomography- and positron emission tomography-screened patients with stage I lung cancer J. Thorac. Cardiovasc. Surg., April 1, 2006; 131(4): 822 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. A. Khan, J. J. Fitzgerald, M. L. Field, I. Soomro, F. D. Beggs, W. E. Morgan, and J. P. Duffy Histological determinants of survival in completely resected T1-2N1M0 nonsmall cell cancer of the lung Ann. Thorac. Surg., April 1, 2004; 77(4): 1173 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Battafarano, S. D. Force, B. F. Meyers, J. Bell, T. J. Guthrie, J. D. Cooper, and G. A. Patterson Benefits of resection for metachronous lung cancer J. Thorac. Cardiovasc. Surg., March 1, 2004; 127(3): 836 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sayar, A. Turna, A. Kilicgun, O. Solak, N. Urerurer, and A. Gurses Prognostic significance of surgical-pathologic multiple-station N1 disease in non-small cell carcinoma of the lung Eur J Cardiothorac Surg, March 1, 2004; 25(3): 434 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Marra, L. Hillejan, G. Zaboura, T. Fujimoto, D. Greschuchna, and G. Stamatis Pathologic N1 non-small cell lung cancer: Correlation between pattern of lymphatic spread and prognosis J. Thorac. Cardiovasc. Surg., March 1, 2003; 125(3): 543 - 553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Battafarano, B. F. Meyers, T. J. Guthrie, J. D. Cooper, and G. A. Patterson Surgical resection of multifocal non-Small cell lung cancer is associated with prolonged survival Ann. Thorac. Surg., October 1, 2002; 74(4): 988 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Jazieh, M. J. Kyasa, G. Sethuraman, and J. Howington Disparities in surgical resection of early-stage non-small cell lung cancer J. Thorac. Cardiovasc. Surg., June 1, 2002; 123(6): 1173 - 1176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Battafarano, J. F. Piccirillo, B. F. Meyers, H.-S. Hsu, T. J. Guthrie, J. D. Cooper, and G. A. Patterson Impact of comorbidity on survival after surgical resection in patients with stage I non-small cell lung cancer J. Thorac. Cardiovasc. Surg., February 1, 2002; 123(2): 280 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Deslauriers Current surgical treatment of nonsmall cell lung cancer 2001 Eur. Respir. J., February 1, 2002; 19(35_suppl): 61S - 70s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. B. Bonnet, D. Bush, G. A. Cheek, J. D. Slater, D. Panossian, C. Franke, and J. M. Slater Effects of Proton and Combined Proton/Photon Beam Radiation on Pulmonary Function in Patients With Resectable but Medically Inoperable Non-small Cell Lung Cancer Chest, December 1, 2001; 120(6): 1803 - 1810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tokuhara, H. Hasegawa, N. Hattori, H. Ishida, T. Taki, S. Tachibana, S. Sasaki, and M. Miyake Clinical Significance of CD151 Gene Expression in Non-Small Cell Lung Cancer Clin. Cancer Res., December 1, 2001; 7(12): 4109 - 4114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Tanaka, K. Yanagihara, Y. Otake, T. Yamada, T. Shoji, R. Miyahara, K. Inui, and H. Wada Prognostic factors in patients with resected pathologic (p-) T1-2N1M0 non-small cell lung cancer (NSCLC) Eur J Cardiothorac Surg, May 1, 2001; 19(5): 555 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Manac'h, M. Riquet, J. Medioni, F. Le Pimpec-Barthes, A. Dujon, and C. Danel Visceral pleura invasion by non-small cell lung cancer: an underrated bad prognostic factor Ann. Thorac. Surg., April 1, 2001; 71(4): 1088 - 1093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Jeremic, Y. Shibamoto, L. Acimovic, N. Nikolic, A. Dagovic, J. Aleksandrovic, and G. Radosavljevic-Asic Second Cancers Occurring in Patients With Early Stage Non-Small-Cell Lung Cancer Treated With Chest Radiation Therapy Alone J. Clin. Oncol., February 15, 2001; 19(4): 1056 - 1063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Asamura, K. Suzuki, H. Kondo, and R. Tsuchiya Where is the boundary between N1 and N2 stations in lung cancer? Ann. Thorac. Surg., December 1, 2000; 70(6): 1839 - 1846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Jazieh, M. Hussain, J. A. Howington, H.J. Spencer, M. Husain, J. T. Grismer, and R. C. Read Prognostic factors in patients with surgically resected stages I and II non-small cell lung cancer Ann. Thorac. Surg., October 1, 2000; 70(4): 1168 - 1171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Deslauriers and J. Gregoire Surgical Therapy of Early Non-Small Cell Lung Cancer Chest, April 1, 2000; 117(2009): 104S - 109S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Ferguson, J. Wang, P. C. Hoffman, D. J. Haraf, J. Olak, G. A. Masters, and E. E. Vokes Sex-associated differences in survival of patients undergoing resection for lung cancer Ann. Thorac. Surg., January 1, 2000; 69(1): 245 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Sawyer, J. A. Bonner, P. M. Gould, R. L. Foote, C. Deschamps, C. M. Lange, and H. Li Factors predicting patterns of recurrence after resection of N1 non-small cell lung carcinoma Ann. Thorac. Surg., October 1, 1999; 68(4): 1171 - 1176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Massard, R. Kessler, B. Gasser, X. Ducrocq, S. Elia, S. Elia, S. Gouzou, and J.-M. Wihlm Local control of disease and survival following bronchoplastic lobectomy for non-small cell lung cancer Eur J Cardiothorac Surg, September 1, 1999; 16(3): 276 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Yoshino, R. Nakanishi, T. Osaki, M. Takenoyama, S. Taga, T. Hanagiri, and K. Yasumoto Unfavorable Prognosis of Patients With Stage II Non-small Cell Lung Cancer Associated With Macroscopic Nodal Metastases Chest, July 1, 1999; 116(1): 144 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. van Velzen, A. Brutel de la Riviere, H. J.J. Elbers, J.-W. J. Lammers, and J. M.M. van den Bosch Type of lymph node involvement and survival in pathologic N1 stage III non-small cell lung carcinoma Ann. Thorac. Surg., April 1, 1999; 67(4): 903 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. George, M. J. Schell, F. C. Detterbeck, and M. A. Socinski Adjuvant Chemotherapy for Resected Non-Small Cell Carcinoma of the Lung: Why We Still Don't Know Oncologist, February 1, 1998; 3(1): 35 - 44. [Abstract] [Full Text]
|
|
|
|
|
|
R. Maruyama, K. Sugio, T. Mitsudomi, G. Saitoh, T. Ishida, and K. Sugimachi RELATIONSHIP BETWEEN EARLY RECURRENCE AND MICROMETASTASES IN THE LYMPH NODES OF PATIENTS WITH STAGE I NON-SMALL-CELL LUNG CANCER J. Thorac. Cardiovasc. Surg., October 1, 1997; 114(4): 535 - 543. [Abstract] [Full Text]
|
|
|
|
|
|
E. van Velzen, R. J. Snijder, A. B. de la Riviere, H. R. J. Elbers, and J. M. M. van den Bosch Lymph Node Type as a Prognostic Factor for Survival in T2 N1 M0 Non-Small Cell Lung Carcinoma Ann. Thorac. Surg., May 1, 1997; 63(5): 1436 - 1440. [Abstract] [Full Text]
|
|
|
|
|
|
W. C. Nugent, M. T. Edney, P. G. Hammerness, B. J. Dain, L. H. Maurer, and J. R. Rigas Non-Small Cell Lung Cancer at the Extremes of Age: Impact on Diagnosis and Treatment Ann. Thorac. Surg., January 1, 1997; 63(1): 193 - 197. [Abstract] [Full Text]
|
|
|
|
|
|
H. Wada, F. Tanaka, K. Yanagihara, T. Ariyasu, T. Fukuse, H. Yokomise, K. Inui, H. Mizuno, O. Ike, and S. Hitomi TIME TRENDS AND SURVIVAL AFTER OPERATIONS FOR PRIMARY LUNG CANCER FROM 1976 THROUGH 1990 J. Thorac. Cardiovasc. Surg., August 1, 1996; 112(2): 349 - 355. [Abstract] [Full Text]
|
|
|
|
|
|
K. Yokoi, N. Miyazawa, and T. Arai Brain Metastasis in Resected Lung Cancer: Value of Intensive Follow-up With Computed Tomography Ann. Thorac. Surg., February 1, 1996; 61(2): 546 - 550. [Abstract] [Full Text]
|
|
|
|
|
|
L. E. Stenbygaard, J. B. Sorensen, and J. E. Olsen METASTATIC PATTERN IN ADENOCARCINOMA OF THE LUNG An autopsy study from a cohort of 137 consecutive patients with complete resection J. Thorac. Cardiovasc. Surg., October 1, 1995; 110(4): 1130 - 1135. [Abstract] [Full Text]
|
|
|
|
|
|
J. C. Nesbitt, J. B. Putnam Jr, G. L. Walsh, J. A. Roth, and C. F. Mountain Survival in early-stage non-small cell lung cancer Ann. Thorac. Surg., August 1, 1995; 60(2): 466 - 472. [Abstract] [PDF]
|
|
|
|
|
|
T. Yano, H. Yokoyama, T. Inoue, H. Asoh, K. Tayama, and Y. Ichinose Surgical results and prognostic factors of pathologic N1 disease in non-small-cell carcinoma of the lungSignificance of N1 level: lobar or hilar nodes J. Thorac. Cardiovasc. Surg., June 1, 1994; 107(6): 1398 - 1402. [Abstract] [Full Text]
|
|
|
|
|
|
R. J. Lewis The role of video-assisted thoracic surgery for carcinoma of the lung: Wedge resection to lobectomy by simultaneous individual stapling Ann. Thorac. Surg., September 1, 1993; 56(3): 762 - 768. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
