ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Matthias Karck
Gideon Uretzky
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Karck, M.
Right arrow Articles by Uretzky, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Karck, M.
Right arrow Articles by Uretzky, G.

Ann Thorac Surg 1992;54:348-351
© 1992 The Society of Thoracic Surgeons

Articles

Optimal level of hypothermia for prolonged myocardial protection assessed by 31P nuclear magnetic resonance

Matthias Karck, MD*,a,b, Antonio Vivi, MSca,b, Maria Tassini, MSca,b, Herzl Schwalb, PhDa,b, Nadir Askenasy, MDa,b, Hadar Merchav, MDa,b, Gil Navon, PhDa,b, Gideon Uretzky, MDa,b

a Joseph Lunenfeld Cardiac Surgery Research Center, Hadassah University Hospital, Jerusalem, Israel
b School of Chemistry, Tel Aviv University, Tel Aviv, Israel

Accepted for publication February 7, 1992.

* Address reprint requests to Dr Karck, Department of Thoracic and Cardiovascular Surgery, Surgical Center, Hannover Medical School, PO Box 610180, Konstanty Gutschowstr 8, 3000 Hannover 61, Germany.

The optimal level of hypothermia during myocardial preservation for cardiac transplantation is not known. Phosphorus 31 nuclear magnetic resonance spectroscopy was used to assess the effect of different preservation temperatures (15 °C in group 1, 4 °C in group 2) on the myocardial high-energy phosphate profiles during prolonged global ischemia and subsequent reperfusion of isolated rat hearts. Adenosine triphosphate depletion during ischemia was more gradual in group 2, leading to significant differences in myocardial adenosine triphosphate concentrations between the two groups after 3 hours of ischemia. The fall in intracellular pH during ischemia was significantly less pronounced in hearts preserved at 4 °C as compared with those at 15 °C. The postischemic recovery of both the left ventricular peak systolic pressure and the maximum rate of increase of left ventricular pressure was enhanced in group 2, although the ischemic period was 3 hours longer than in group 1. Hypothermia at 4 °C as compared with 15 °C appears to prolong myocardial protection with respect to adenosine triphosphate preservation, prevention of the fall in intracellular pH, and the enhancement of postischemic hemodynamic recovery.




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Ohkado, H. Cao-Danh, K. E. Sommers, and P. J. del Nido
Evaluation of highly buffered low-calcium solution for long-term preservation of the heartComparison with University of Wisconsin solution
J. Thorac. Cardiovasc. Surg., October 1, 1994; 108(4): 762 - 771.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1992 by The Society of Thoracic Surgeons.