| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1992;54:199-204
© 1992 The Society of Thoracic Surgeons
Section of General Thoracic Surgery, Department of Surgery, and Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota USA
* Address reprints to Dr Trastek, 200 First St, SW, Rochester, MN 55905.
Between 1982 and 1991, 19 patients (17 men and 2 women) with Barrett's esophagus, 10 of whom were in a surveillance program, were found to have high-grade dysplasia without evidence of invasive carcinoma. Median age was 66 years (range, 30 to 79 years). Heartburn was the most common presenting symptom. Esophagoscopy at the time of high-grade dysplasia diagnosis demonstrated normal Barrett's mucosa in 10 patients (53%), shallow ulcers in 3, slight mucosal irregularities in 2, small mucosal nodules in 2, stricture in 1, and shallow ulcer with stricture in 1. Eighteen patients underwent esophagectomy. There were no operative deaths. Nine patients (50%) had invasive carcinoma. Postsurgical stage was stage 0 in 9 patients, stage I in 6, stage IIA in 2, and stage IIB in 1. Median follow-up was 34 months (range, 2 to 116 months). Recurrent cancer developed in 2 patients. Overall 5-year survival was 66.7%; 5-year survival for patients with stage 0 disease was 100% and for stage I and II disease, 35.7%. We conclude that high-grade dysplasia is an indication for esophageal resection because of the high rate of associated early invasive carcinoma and that resection can be done safely with the expectation of excellent long-term survival. Because of these findings, we continue to recommend endoscopic surveillance in all patients with Barrett's esophagus.
This article has been cited by other articles:
|
|
 |
|
  W. Zhu, H. D. Appelman, J. K. Greenson, S. R. Ramsburgh, M. B. Orringer, A. C. Chang, and B. J. McKenna A Histologically Defined Subset of High-Grade Dysplasia in Barrett Mucosa Is Predictive of Associated Carcinoma Am J Clin Pathol, July 1, 2009; 132(1): 94 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R D Odze Diagnosis and grading of dysplasia in Barrett's oesophagus. J. Clin. Pathol., October 1, 2006; 59(10): 1029 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Moraca and D. E. Low Outcomes and Health-Related Quality of Life After Esophagectomy for High-Grade Dysplasia and Intramucosal Cancer Arch Surg, June 1, 2006; 141(6): 545 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Soetikno, T. Kaltenbach, R. Yeh, and T. Gotoda Endoscopic Mucosal Resection for Early Cancers of the Upper Gastrointestinal Tract J. Clin. Oncol., July 10, 2005; 23(20): 4490 - 4498. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Reed, G. Tolis Jr, B. H. Edil, J. S. Allan, D. M. Donahue, H. A. Gaissert, A. C. Moncure, J. C. Wain, C. D. Wright, and D. J. Mathisen Surgical Treatment of Esophageal High-Grade Dysplasia Ann. Thorac. Surg., April 1, 2005; 79(4): 1110 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N J Shaheen, J M Inadomi, B F Overholt, and P Sharma What is the best management strategy for high grade dysplasia in Barrett's oesophagus? A cost effectiveness analysis Gut, December 1, 2004; 53(12): 1736 - 1744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M S Dar, J R Goldblum, T W Rice, and G W Falk Can extent of high grade dysplasia in Barrett's oesophagus predict the presence of adenocarcinoma at oesophagectomy? Gut, April 1, 2003; 52(4): 486 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Inadomi, R. Sampliner, J. Lagergren, D. Lieberman, A M. Fendrick, and N. Vakil Screening and Surveillance for Barrett Esophagus in High-Risk Groups: A Cost-Utility Analysis Ann Intern Med, February 4, 2003; 138(3): 176 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A H Ormsby, R E Petras, W H Henricks, T W Rice, L A Rybicki, J E Richter, and J R Goldblum Observer variation in the diagnosis of superficial oesophageal adenocarcinoma Gut, November 1, 2002; 51(5): 671 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Headrick, F. C. Nichols III, D. L. Miller, M. S. Allen, V. F. Trastek, C. Deschamps, C. D. Schleck, A. M. Thompson, and P. C. Pairolero High-grade esophageal dysplasia: long-term survival and quality of life after esophagectomy Ann. Thorac. Surg., June 1, 2002; 73(6): 1697 - 1703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Shaheen and D. F. Ransohoff Gastroesophageal Reflux, Barrett Esophagus, and Esophageal Cancer: Scientific Review JAMA, April 17, 2002; 287(15): 1972 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Klaus and R. A. Hinder Indications for Antireflux Surgery in Barrett's Surgical Innovation, December 1, 2001; 8(4): 234 - 239. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Walch, J. Mueller, H. Hofler, and M. Werner Re: Clonal Expansion and Loss of Heterozygosity at Chromosomes 9p and 17p in Premalignant Esophageal (Barrett's) Tissue J Natl Cancer Inst, July 19, 2000; 92(14): 1182 - 1182. [Full Text] [PDF]
|
|
|
|
|
|
J W van Sandick, J J B van Lanschot, B W Kuiken, G N J Tytgat, G J A Offerhaus, and H Obertop Impact of endoscopic biopsy surveillance of Barrett's oesophagus on pathological stage and clinical outcome of Barrett's carcinoma Gut, August 1, 1998; 43(2): 216 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Hoff, J. L. Sawyers, C. D. Blanke, H. Choy, and J. R. Stewart Prognosis of Adenocarcinoma Arising in Barrett's Esophagus Ann. Thorac. Surg., January 1, 1998; 65(1): 176 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Ferguson and K. S. Naunheim RESECTION FOR BARRETT'S MUCOSA WITH HIGH-GRADE DYSPLASIA: IMPLICATIONS FOR PROPHYLACTIC PHOTODYNAMIC THERAPY J. Thorac. Cardiovasc. Surg., November 1, 1997; 114(5): 824 - 829. [Abstract] [Full Text]
|
|
|
|
|
|
A. J. McLarty, C. Deschamps, V. F. Trastek, M. S. Allen, P. C. Pairolero, and W. S. Harmsen Esophageal Resection for Cancer of the Esophagus: Long-Term Function and Quality of Life Ann. Thorac. Surg., June 1, 1997; 63(6): 1568 - 1571. [Abstract] [Full Text]
|
|
|
|
|
|
M. D. Iannettoni, S. S. Lee, M. R. Bonnell, T. L. Sell, R. I. Whyte, M. B. Orringer, and D. G. Beer Detection of Barrett's Adenocarcinoma of the Gastric Cardia With Sucrase Isomaltase and p53 Ann. Thorac. Surg., November 1, 1996; 62(5): 1460 - 1465. [Abstract] [Full Text]
|
|
|
|
|
|
E. A. Davis and R. F. Heitmiller Esophagectomy for Benign Disease: Trends in Surgical Results and Management Ann. Thorac. Surg., August 1, 1996; 62(2): 369 - 372. [Abstract] [Full Text]
|
|
|
|
|
|
A. G. Little Barrett's Esophagus Ann. Thorac. Surg., July 1, 1996; 62(1): 315 - 315. [Full Text]
|
|
|
|
|
|
M. L. McDonald, V. F. Trastek, M. S. Allen, C. Deschamps, and P. C. Pairolero BARRETT'S ESOPHAGUS: DOES AN ANTIREFLUX PROCEDURE REDUCE THE NEED FOR ENDOSCOPIC SURVEILLANCE? J. Thorac. Cardiovasc. Surg., June 1, 1996; 111(6): 1135 - 1140. [Abstract] [Full Text]
|
|
|
|
|
|
P. Monnier, J.-B. Ollyo, C. Fontolliet, and M. Savary Epidemiology and Natural History of Reflux Esophagitis Surgical Innovation, March 1, 1995; 2(1): 2 - 9. [Abstract] [PDF]
|
|
|
|
|
|
J. H. Peters, G. W. B. Clark, A. P. Ireland, P. Chandrasoma, T. C. Smyrk, and T. R. DeMeester Outcome of adenocarcinoma arising in Barrett's esophagus in endoscopically surveyed and nonsurveyed patients J. Thorac. Cardiovasc. Surg., November 1, 1994; 108(5): 813 - 822. [Abstract] [Full Text]
|
|
|
|
|
|
G. W. B. Clark, J. H. Peters, A. P. Ireland, A. Ehsan, J. A. Hagen, M. T. Kiyabu, C. G. Bremner, and T. R. DeMeester Nodal metastasis and sites of recurrence after en bloc esophagectomy for adenocarcinoma Ann. Thorac. Surg., September 1, 1994; 58(3): 646 - 654. [Abstract] [PDF]
|
|
|
|
|
|
T. Lerut, W. Coosemans, D. Van Raemdonck, B. Dillemans, P. De Leyn, J. M. Marnette, K. Geboes, and S. b. T. R. DeMeester Surgical treatment of Barrett's carcinomaCorrelations between morphologic findings and prognosis J. Thorac. Cardiovasc. Surg., April 1, 1994; 107(4): 1059 - 1066. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
