HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bolling, S. F. Articles by Gallagher, K. P. Search for Related Content PubMed PubMed Citation Articles by Bolling, S. F. Articles by Gallagher, K. P.

The Annals of Thoracic Surgery, Vol 54, 93-98, Copyright © 1992 by The Society of Thoracic Surgeons

ARTICLES

Acadesine (AICA-riboside) improves postischemic cardiac recovery

SF Bolling, MA Groh, AM Mattson, RA Grinage and KP Gallagher
Department of Surgery (Thoracic Surgery), University of Michigan, Ann Arbor.

To test if acadesine (5-aminoimidazole-4-carboxamide riboside), a purine precursor, has cardioprotective effects, 16 dogs were placed on total cardiopulmonary bypass and subjected to global myocardial ischemia. Hemodynamic recovery was compared between a control (n = 8) group receiving standard cardioplegia and an acadesine (n = 8) group pretreated with intravenous acadesine (2.5 mg.kg-1.min-1 for 5 minutes, then 0.5 mg.kg-1.min-1) before ischemia, during ischemia, and until 10 minutes after removal of the aortic cross-clamp. Additionally, in the acadesine group the cardioplegia also contained 20 mumol/L acadesine. While the dogs were on cardiopulmonary bypass, global warm myocardial ischemia was induced by aortic cross-clamping for 5 minutes under normothermic conditions to simulate an angioplasty accident. Five minutes after aortic cross-clamping, hypothermic cardioplegia (30 mL/kg) was administered. The left anterior descending coronary artery was occluded before the first infusion of cardioplegia to simulate poor cardioplegia delivery that can occur during an emergency coronary artery bypass procedure after an angioplasty accident. The left anterior descending artery occlusion was released, and additional cardioplegia (15 mL/kg) infusions were made every 30 minutes thereafter during 120 minutes of cardioplegic ischemia. Thirty minutes after reperfusion, all animals in both groups were weaned from bypass and recovery data were obtained to compare with baseline preischemic values. There were no significant differences in heart rate, left atrial pressure, or systemic vascular resistance between groups after weaning from bypass. Peak developed pressure recovered to 79% +/- 19% (mean +/- standard deviation) of baseline in the acadesine group compared with 56% +/- 22% in the control group (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				T. O. Cheng, A. Jovanovic, J. R. Lopez, A. E. Alekseev, W. K. Shen, and A. Terzic Adenosine and K+-Induced Ca2+ Loading Ann. Thorac. Surg., August 1, 1997; 64(2): 588 - 589. [Full Text]

				P. Menasche, W. R. E. Jamieson, W. Flameng, M. K. Davies, and on behalf of the Multinational Acadesine Study Gro ACADESINE: A NEW DRUG THAT MAY IMPROVE MYOCARDIAL PROTECTION IN CORONARY ARTERY BYPASS GRAFTINGResults of the first international multicenter study J. Thorac. Cardiovasc. Surg., October 1, 1995; 110(4): 1096 - 1106. [Abstract] [Full Text]

				E. R. Rosenkranz Substrate Enhancement of Cardioplegic Solution: Experimental Studies and Clinical Evaluation Ann. Thorac. Surg., September 1, 1995; 60(3): 797 - 800. [Abstract] [Full Text]

				W. R. Chitwood Jr and C. L. Wixon Update in Myocardial Protection Ann. Thorac. Surg., January 1, 1995; 59(1): 253 - 254. [Full Text]

				W. D. Dietrich, L. P. Miller, R. Prado, S. Dewanjee, N. Alexis, M. K. Dewanjee, and H. Gruber Acadesine Reduces Indium-Labeled Platelet Deposition After Photothrombosis of the Common Carotid Artery in Rats Stroke, January 1, 1995; 26(1): 111 - 116. [Abstract] [Full Text]