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The Annals of Thoracic Surgery, Vol 53, 957-964, Copyright © 1992 by The Society of Thoracic Surgeons
WD Lazenby, W Ko, JA Zelano, N Lebowitz, YT Shin, OW Isom and KH Krieger
Eleven dogs were subjected to a 150-minute period of cardiopulmonary bypass
that consisted of a high-flow, normothermic phase, a high-flow, hypothermic
phase, a low-flow, hypothermic phase, and then a high-flow, rewarming
phase. Regional blood flow and oxygen consumption to the brain, intestines,
kidney, and hind limb were determined at baseline and at 10-minute
intervals during cardiopulmonary bypass. Blood flow to the carotid artery,
superior mesenteric artery, and renal artery declined significantly with
hypothermic cardiopulmonary bypass whereas blood flow to the femoral artery
increased significantly. Although total body oxygen consumption returned to
baseline values at the end of the rewarming phase, oxygen consumption for
these regions differed somewhat from their baseline values. We conclude
that blood flow during hypothermic cardiopulmonary bypass is shunted to
skeletal muscle, particularly with high pump flows. Additionally, the
return of total body oxygen consumption to baseline after rewarming is not
necessarily reflected at the regional level.
ARTICLES
Effects of temperature and flow rate on regional blood flow and metabolism during cardiopulmonary bypass
Division of Cardiothoracic Surgery, New York Hospital-Cornell Medical Center, New York 10021.
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