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Ann Thorac Surg 1992;53:1114-1116
© 1992 The Society of Thoracic Surgeons

Articles

Development of malignant hyperthermia during mitral valve replacement

Reed D. Quinn, MD, Walter E. Pae, MD*, Suzan A. McGary, MD, G.Scott Wickey, MD

Division of Cardiothoracic Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania USA

Accepted for publication October 10, 1991.

* Address reprint requests to Dr Pae, Division of Cardiothoracic Surgery, Department of Surgery, C4608, The Milton S. Hershey Medical Center, 500 University Dr, Hershey, PA 17033 USA.

Malignant hypothermia is a genetically predisposed, potentially fatal disorder triggered by anesthetic agents. The early diagnosis and treatment of malignant hyperthermia is essential, yet often difficult, because the signs and symptoms of this disorder are not unique to the disease. When the patient is also undergoing cardiopulmonary bypass ihis disorder may be very difficult to recognize. In this article, we report a case of malignant hyperthermia diagnosed during mitral valve replacement and discuss the preoperative and postoperative management possibilities. The unusualness of this case stems from the fact that the patient had centronuclear myopathy. Although reported with other types of myopathies, centronuclear myopathy has rarely been associated with malignant hyperthermia. This episode of malignant hyperthermia was diagnosed by intraoperative measurements showing increased oxygen consumption despite hypothermic cardiopulmonary bypass.




This article has been cited by other articles:


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 J. Thorac. Cardiovasc. Surg.Home page
T. Metterlein, W. Zink, E. Kranke, A. Haneya, B. Graf, and P. Kranke
Cardiopulmonary bypass in malignant hyperthermia susceptible patients: A systematic review of published cases
J. Thorac. Cardiovasc. Surg., June 1, 2011; 141(6): 1488 - 1495.
[Abstract] [Full Text] [PDF]


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