| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1992;53:1068-1073
© 1992 The Society of Thoracic Surgeons
Department of Cardiothoracic Surgery, University Hospital, Lund, Sweden
Accepted for publication December 6, 1991.
* Address reprint request to Dr Steen, Department of Cardiothoracic Surgery. University Hospital of Lund, S-221 85 Lund, Sweden.
This study compares the vasodilating effect of endothelium-derived relaxing factors (EDRFs) in free arterial grafts with that in their normal control vessels. The infrarenal aorta of Sprague-Dawley rats was transplanted into the same position in other inbred recipient rats. A Krebs buffer solution (4 °C) served as the preservation solution. The ischemic time for the grafts (n = 8) was 42 ± 1 minutes. Two grafts were studied after 3 days and six grafts, after 60 days. Ring segments were cut from all vessels, and isometric contractions were recorded in organ baths. The vessel segments were constricted with noradrenaline, a thromboxane A2 mimic (U-46619), or prostaglandin F2α. Concentration-response curves with acetylchollne, which was used as the endothelium-stimulating substance causing release of EDRFs, were obtained. The patency of the grafts was 100%. Acetylcholine induced relaxation in all vessel segments with intact intima, whereas no relaxation was seen when the endothelium was manually removed. No significant differences were found between the grafts and the normal control vessels. Histology of the 60-day grafts showed elastomuscular arteries without intimai thickening and a media consisting of eight to ten muscle layers interrupted by five to six elastic lamellae. Scanning electron micruscopy showed no major differences between normal endothelium and the endothelium of 3-day or 60-day grafts. This study indicates that free elastomuscular arterial grafts, in which the morphology of the intima is preserved, will retain their full ability to release EDRFs.
This article has been cited by other articles:
|
|
 |
|
  R. Ingemansson, A. Budrikis, R. Bolys, T. Sjoberg, and S. Steen Effect of Flush-Perfusion on Vascular Endothelial and Smooth Muscle Function Ann. Thorac. Surg., October 1, 1997; 64(4): 1075 - 1081. [Abstract] [Full Text]
|
|
|
|
|
|
R. Ingemansson, R. Bolys, A. Budrikis, A. Lindgren, T. Sjoberg, and S. Steen Addition of Calcium to Euro-Collins Solution Is Essential for 24-Hour Preservation of the Vasculature Ann. Thorac. Surg., February 1, 1997; 63(2): 408 - 413. [Abstract] [Full Text]
|
|
|
|
|
|
R. Ingemansson, A. Budrikis, R. Bolys, T. Sjoberg, and S. Steen Effect of Temperature in Long-Term Preservation of Vascular Endothelial and Smooth Muscle Function Ann. Thorac. Surg., May 1, 1996; 61(5): 1413 - 1417. [Abstract] [Full Text]
|
|
|
|
|
|
R. Ingemansson, T. Sjoberg, and S. Steen Importance of Calcium in Long-Term Preservation of the Vasculature Ann. Thorac. Surg., April 1, 1996; 61(4): 1158 - 1162. [Abstract] [Full Text]
|
|
|
|
|
|
R. Ingemansson, G. Massa, R. K. Pandita, T. Sjoberg, and S. Steen Perfadex is superior to euro-collins solution regarding 24-hour preservation of vascular function Ann. Thorac. Surg., November 1, 1995; 60(5): 1210 - 1214. [Abstract] [PDF]
|
|
|
|
|
|
R. Ingemansson, T. Sjoberg, G. Massa, and S. Steen Long-term preservation of vascular endothelium and smooth muscle Ann. Thorac. Surg., May 1, 1995; 59(5): 1177 - 1181. [Abstract] [PDF]
|
|
|
|
|
|
G. Massa, R. Ingemansson, T. Sjoberg, and S. Steen Endothelium-dependent relaxation after short-term preservation of vascular grafts Ann. Thorac. Surg., October 1, 1994; 58(4): 1117 - 1122. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
