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Ann Thorac Surg 1992;53:1025-1032
© 1992 The Society of Thoracic Surgeons

Articles

Skeletal muscle ventricles with improved thromboresistance: 28 weeks in circulation

Alberto Pochettino, MD, Frank W. Mocek, MD, Huiping Lu, MD, Robert L. Hammond, BA, Ali D. Spanta, MD, Timothy L. Hooper, MD, FRCS, Hiroshi Niinami, MD, Renato Ruggiero, MD, Michael Colson, MS, Larry W. Stephenson, MD*

Division of Cardiothoracic Surgery, Wayne State University School of Medicine, Detroit, Michigan USA

Accepted for publication November 25, 1991.

* Address reprint requests to Dr Stephenson, Division of Cardiothoracic Surgery, Wayne State University, Harper Professional Building, Suite 228, 4160 John R, Detroit, MIM 48201 USA.

Skeletal muscle ventricles (SMVs) were constructed from the left latissimus dorsi in 22 mongrel dogs. The configuration of these SMVs was different from those previously reported. The animals were divided into two groups: group A (n = 11) SMVs rested for 10 weeks after construction; group B (n = 11) SMVs rested for 18 weeks. At the end of the delay period, SMVs were tested in vivo with a mock circulation device. The SMVs in group B developed stroke work greater than those in group A. After acute testing, SMVs (n = 12) were connected to the descending thoracic aorta and stimulated to contract during diastole. Aortic diastolic counterpulsation was achieved in all dogs, with 9 animals surviving from 1 to beyond 28 weeks. In all of the dogs surviving 1 week or more, the SMVs remained free of thrombus. Aspirin was used as the only antithrombotic agent. Skeletal muscle ventricles in this study were able to develop stroke work similar to that previously reported, intermediate between that of the right and left ventricular stroke work, with a significantly decreased incidence of thromboembolism.




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