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Ann Thorac Surg 1992;53:1018-1022
© 1992 The Society of Thoracic Surgeons

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Articles

Influence of alprostadil on pulmonary dysfunction after a cardiac operation

Department of Thoracic and Cardiovascular Surgery, Sahlgrenska Hospital, Göeborg University, Göteborg, Sweden

Accepted for publication October 30, 1991.

^_* Address reprint requests to Dr El-Gatit, Department of Thoracic and Cardiovascular Surgery, Sahlgrenska Hospital, Göteborg University, S-413 45 Göteborg, Sweden.

To test the effects of alprostadil on pulmonary dysfunction after caediac operations, we studied 24 male patients undergoing; aortocoronary bypass. Twelve were given an intravenous infusion of alprostadil (synthetic prostaglandin E₁), 20 ng · kg^–1 · min ^–1, in a double-blind manner during operation; the other 12 were controls. Duration of artificial respirator use and frequent blood gas analyses were used to assess postoperative pulmonary function. Use of the artificial respirator postoperatively was significantly lower in the prostaglandin group (mean time, 5.25 ± 1.81 hours) compared with the controls (mean time, 8.34 ± 4.35 hours) (p = 0.047). The proportion of patients with hypercapnia and with hypoxia determined every 4 hours for the first 24 hours after extubation was significantly lower in the prostaglandin group compared with the controls (p < 0.0001). These results indicate that synthetic prostaglandin E₁ may play a role in protecting lung tissue during extracorporeal circulation.

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