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Ann Thorac Surg 1992;53:833-838
© 1992 The Society of Thoracic Surgeons
a Department of Cardiothoracic Surgery, Oxford Heart Centre, Oxford, England
b Nuffield Department of Surgery John Radcliffe Hospital, Oxford, England
Accepted for publication October 15, 1991.
* Address reprint requests to Dr Butler, Department of Cardiothoracic Surgery, Oxford Heart Centre, John Radcliffe Hospital, Headington, Oxford OX3 9DU, England.
The systemic inflammatory response to cardiopulmonary bypass was assessed in 20 patients who underwent elective coronary artery bypass grafting with flat-sheet membrane oxygenation (group 1; n = 10; age, 59 ± 5 years) or bubble oxygenation (group II; n = 10; age, 62 ± 8 years). The duration of cardiopulmonary 'pass was 46 ± 12 minutes in group I and 47 ± 15 minut in group II. Plasma interieukin-6, plasma interleukin-.β, transpulmonary leukocyte counts, pulmonary hemodynamic variables, and respiratory index were determined in all patients perioperatively. The plasma interleukin-6 response (median [range]) was similar in both groups at the end of the operation, peaked 4 hours postoperatively (99 [30 to 320] pg/mL in group I; 123 [21 to 300] pg/mL in group II; p > 0.05), and remained elevated 48 hours postoperatively (76 [9 to 140] pg/mL in group I; 65 [25 to 159] pg/mL in group II; p > 0.05). No significant interleukin-1β response was demonstrated. Pulmonary neutrophil and lymphocyte sequestation was observed on commencement of cardiopulmonary bypass in group II but did not occur in either group on discontinuation of cardiopulmonary bypass. Pulmonary vascular resistance at the end of the operation (82 [48 to 320] dynes · s · cm–5 in group I; 119 [54 to 385] dynes · s · cm–5 in group II; p > 0.05) was similar to preoperative values (151 [30 to 327] dynes · s · cm–5 in group I; 185 [62 to 291] dynes · s · cm–5 in group II; p > 0.05). The respiratory index at the end of the operation was similarly and significantly increased in both groups (1.26 [0.92 to 4.17] in group I; 1.44 [0.73 to 3.30] in group II). Cardiopulmonary bypass with both membrane and bubble oxygenation was followed by a significant interleukin-6 response; pulmonary neutrophil sequestration did not occur after cardiopulmonary bypass, although significant impairment of oxygenation was still found after perfusion of short duration.
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