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Ann Thorac Surg 1992;53:680-683
© 1992 The Society of Thoracic Surgeons

Articles

DNA content in correlation with postsurgical stage in non-small cell lung cancer

Ned Z. Carp, MD, Douglas D. Ellison, MD, Patrick F. Brophy, MD, Perry Watts, BS, Ming-Chen Chang, MD, Steven M. Keller, MD*

Departments of Surgical Oncology, Pathology, and Statistics, Fox Chase Cancer Center, and Section of Surgical Oncology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

Accepted for publication October 9, 1991.

* Address reprint requests to Dr Keller, Department of Surgical Oncology, Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111.

The relationship between DNA content, TNM stage, tumor size, grade, histology, and disease-free survival was assessed in a retrospective study of patients with non-small cell lung cancer who had undergone resection and complete mediastinal lymph node dissection. Flow cytometric analysis was performed on paraffin-embedded tissue of 90 consecutive patients. The patients were analyzed both as a group and by individual stage. Median follow-up was 11 months (range, 1 to 35 months). Aneuploid tumors were not significantly different from diploid tumors with regard to pathologic TNM stage (p = 0.34), size (p = 0.5), grade (p = 0.5), or histology (p = 0.34). Disease-free survival of patients with aneuploid tumors was not significantly different than that of patients whose tumors had normal DNA content (p = 0.69). DNA content did not correlate with established prognostic factors in patients with non-small cell lung cancer who underwent resection and complete mediastinal lymph node dissection.




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