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Michael K. Pasque
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Ann Thorac Surg 1992;53:635-641
© 1992 The Society of Thoracic Surgeons

Articles

Management of dysfunction in the transplanted lung: Experience with 7 clinical cases

David A. Haydock, FRACS1, Elbert P. Trulock, MD, Larry R. Kaiser, MD, Simon R. Knight, FRACS2, Michael K. Pasque, Md, Joel D. Cooper, M* the Washington University Lung Transplant Group

Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA

Accepted for publication September 16, 1991.

* Address reprint requests to Dr Cooper, Cardiothoracic Surgery, Washington University School of Medicine, Suite 3108 Queeny Tower, 1 Barnes Hospital Plaza, St Louis, MO 63110.

In a series of 34 lung transplant patients, donor lung dysfunction occurred on 7 occasions. One patient underwent retransplantation and the remaining 6 were treated conservatively. Survival was 100% in the donor lung dysfunction group. Percent predicted forced expiratory volume in 1 second, carbon monoxide diffusion, room air oxygen tension, and distance walked in 6 minutes were all lower (p < 0.05) at 1 month after transplantation in those patients with donor lung dysfunction as compared with those without. These differences were not significant at 3 months after transplantation. We conclude that donor lung dysfunction can usually be managed conservatively with satisfactory results. Longer follow-up of this group of patients will be necessary to determine the long-term consequences of early graft injury.




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