HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Ryota Shirakura Hikaru Matsuda Susumu Nakano Yuji Miyamoto Norihide Fukushima Yasunaru Kawashima Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shirakura, R. Articles by Kawashima, Y. Search for Related Content PubMed PubMed Citation Articles by Shirakura, R. Articles by Kawashima, Y.

Ann Thorac Surg 1992;53:440-444
© 1992 The Society of Thoracic Surgeons

---

Articles

Cardiac function and myocardial performance of 24-hour-preserved asphyxiated canine hearts

First Department of Surgery, Osaka University Medical School, Osaka, Japan

Accepted for publication August 22, 1991.

^_* Address reprint requests to Dr Shirakura, First Department of Surgery, Osaka University Medical School, 1-1-50 Fukushima, Fukushima-Ku, Osaka 553, Japan.

A method of 24-hour storage of asphyxiated canine hearts for orthotopic cardiac transplantation was studied to expand the geographical size of the donor pool. Left ventricular function of asphyxiated hearts preserved for 24 hours (group 1, n = 8) was compared with that of hearts donated on-site (group 2, n = 5). Group 1 donors were preheated with verapamil hydrochloride, propranolol hydrochloride, and prostacyclin. The donor hearts were perfused with warm blood cardioplegia in situ after 10 minutes of asphyxiation and then perfused with cold crystalloid cardioplegia for 2 hours. The hearts were excised and stored in ice-cold University of Wisconsin solution for 22 hours. At orthotopic transplantation, coronary perfusion with warm blood cardioplegia was performed before the graft aorta was undamped. Conventional cardiac variables (eg, cardiac output and maximum rate of rise of left ventricular pressure), myocardial performance, and diastolic compliance of grafted hearts were assessed 1 hour after weaning from bypass. All recipients in both groups were easily weaned from cardiopulmonary bypass without inotropic agents, and there were no significant differences in cardiac variables between the two groups. These results strongly suggest that cadaver hearts can be preserved for 24 hours with satisfactory cardiac function.

This article has been cited by other articles:

				Y. Kotani, K. Ishino, S. Osaki, O. Honjo, T. Suezawa, K. Kanki, C. Yutani, and S. Sano Efficacy of MCI-186, a free-radical scavenger and antioxidant, for resuscitation of nonbeating donor hearts J. Thorac. Cardiovasc. Surg., June 1, 2007; 133(6): 1626 - 1632. [Abstract] [Full Text] [PDF]

				S. Osaki, K. Ishino, Y. Kotani, O. Honjo, T. Suezawa, K. Kanki, and S. Sano Resuscitation of Non-Beating Donor Hearts Using Continuous Myocardial Perfusion: The Importance of Controlled Initial Reperfusion Ann. Thorac. Surg., June 1, 2006; 81(6): 2167 - 2171. [Abstract] [Full Text] [PDF]

				J. T. Cope, M. C. Mauney, D. Banks, O. A. R. Binns, C. L. Moore, J. J. Rentz, K. S. Shockey, R. C. King, I. L. Kron, and C. G. Tribble Intravenous Phenylephrine Preconditioning of Cardiac Grafts From Non-Heart-Beating Donors Ann. Thorac. Surg., June 1, 1997; 63(6): 1664 - 1668. [Abstract] [Full Text]

				J. T. Cope, M. C. Mauney, D. Banks, O. A. R. Binns, N. F. De Lima, S. A. Buchanan, K. S. Shockey, S. W. Wilson, I. L. Kron, and C. G. Tribble Controlled Reperfusion of Cardiac Grafts From Non--Heart-Beating Donors Ann. Thorac. Surg., November 1, 1996; 62(5): 1418 - 1423. [Abstract] [Full Text]

				N. Fukushima, R. Shirakura, S. Nakata, M. Kaneko, S. Miyagawa, Y. Naka, J.-C. Chang, G. Matsumiya, S. Nakano, and H. Matsuda Study of efficacies of leukocyte-depleted terminal blood cardioplegia in 24-hour preserved hearts Ann. Thorac. Surg., December 1, 1994; 58(6): 1651 - 1656. [Abstract] [PDF]