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Ann Thorac Surg 1992;53:247-252
© 1992 The Society of Thoracic Surgeons

Articles

Activated neutrophils impair rabbit heart recovery after hypothermic global ischemia

Mary Lee Myers, MD*,a,b, Christopher Webb, BSca,b, Margaret Moffat, PhDa,b, Donald McIver, MD, PhDa,b, Rolando Del Maestro, MD, PhDa,b

a Division of Cardiovascular Surgery and Brain Research Laboratory, Victoria Hospital London, Ontario, Canada
b Department of Pharmacology and Toxicology, University of Western Ontario, London, Ontario, Canada

Accepted for publication August 1, 1991.

* Address reprint requests to Dr Myers, 370 South St, No C101, London, Ont, Canada, N6B 1B8.

Cardiopulmonary bypass is known to cause neutrophil activation, and activated neutrophils appear to be of importance in myocardial reperfusion injury. This study examined the effect of a preischemic infusion of activated neutrophils on the recovery of myocardial function after 40 minutes of hypothermic global ischemia. Studies were carried out in three groups of Langendorff-perfused rabbit hearts: control, control (unactivated) neutrophil infusion, and phorbal myristate acetate-activated neutrophil infusion. The activated neutrophil group showed significant deterioration in function during the activated neutrophil infusion. All three groups demonstrated significant depression of function initially after reperfusion, but the two control groups subsequently recovered to baseline levels. The activated neutrophil group, however, showed a persistent significant depression in ventricular force, rate of ventricular tension development, and rate of ventricular relaxation as well as a significant increase in coronary vascular resistance. It is concluded that activated neutrophils depress myocardial function and contribute to impaired recovery of function after global hypothermic ischemia.




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