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The Annals of Thoracic Surgery, Vol 53, 64-72, Copyright © 1992 by The Society of Thoracic Surgeons
CN Steimle, TP Guynn, ML Morganroth, SF Bolling, K Carr and GM Deeb
The role of neutrophils (PMNs) in ischemia-reperfusion injury after lung
transplantation is unclear. If PMNs are involved in ischemia- reperfusion
injury in the intact rat, then PMNs should sequester in the injured lung
and PMN-depleted rats should develop less injury. Group A rats were treated
with a rabbit anti-rat PMN antibody causing profound neutropenia (less than
100 PMNs/microL) and group B with control serum (greater than 2,000
PMNs/microL). Rats were anesthetized and left lung ischemia was sustained
for 90 or 180 minutes by clamping the bronchus and the pulmonary artery and
vein. Lung injury was quantified by the accumulation of radiolabeled (125I)
albumin in ischemic left and nonischemic right lungs (cpm per gram of
lung/cpm per gram of blood). Ischemia caused significant lung injury (p
less than 0.05) in both PMN- depleted (albumin leak index: 90 min, 0.208;
180 min, 0.218) and nondepleted (90 min, 0.222; 180 min, 0.241) animals
compared with nonischemic controls (depleted: 90 min, 0.050; 180 min,
0.100; nondepleted: 90 min, 0.063; 180 min, 0.101); microscopy also
demonstrated lung injury. The injury was not associated with PMN
sequestration as shown by light microscopy. Thus, we conclude that PMNs are
not necessary for ischemia-reperfusion injury and PMN-depletion does not
attenuate ischemia-reperfusion injury.
ARTICLES
Neutrophils are not necessary for ischemia-reperfusion lung injury
Department of Thoracic Surgery, University of Michigan Hospitals, Ann Arbor.
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