ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Adrian H. Chester
John R. Pepper
Magdi H. Yacoub
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O'Neil, G. S.
Right arrow Articles by Yacoub, M. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O'Neil, G. S.
Right arrow Articles by Yacoub, M. H.

Ann Thorac Surg 1991;52:1310-1314
© 1991 The Society of Thoracic Surgeons

Articles

Vascular reactivity of human internal mammary and gastroepiploic arteries

Gregory S. O'Neil, BSc, Adrian H. Chester, BSc, Catherine J. Schyns, Samad Tadjkarimi, MD, John R. Pepper, FRCS, Magdi H. Yacoub, FRCS*

National Heart and Lung Institute, Harefield Hospital, Harefield, Middlesex, United Kingdom

Accepted for publication August 8, 1991.

* Address reprint requests to Prof Yacoub, Thoracic and Cardiac Surgical Unit, Harefield Hospital, Harefield, Middlesex UB96JH, United Kingdom.

Patency rates of bypass graft conduits are thought to be influenced by the determinants of vascular tone. This study has comparatively examined the response of the human internal mammary and gastroepiploic arteries to potassium, noradrenaline, dopamine, 5-hydroxytryptamine, thromboxane, and histamine. The response to potassium was significantly greater in the gastroepiploic artery (Emax = 79.5 ± 9.6 mN) than in the internal mammary artery (Emax = 27.0 ± 6.4 mN). Dose-related constrictions were observed in both vessels to all agonists except histamine, which was ineffective in the gastroepiploic artery. Noradrenaline and dopamine produced comparable dose-related constrictions in each vessel, with similar EC50 and Emax (expressed as a percentage of potassium response) values, but 5-hydroxytryptamine (Emax, gastroepiploic = 10.8% ± 1.9%; internal mammary = 71.8% ± 21.2%) and thromboxane (Emax gastroepiploic = 116.7% ± 4.0%; internal mammary = 169.6% ± 19.4%) were more efficacious in their constriction of the mammary artery; the potencies were similar. We conclude that there is a heterogeneity of response to some vasoconstrictors between the human internal mammary and gastroepiploic arteries. The internal mammary artery may be more predisposed to events that initiate vasospastic disorders.




This article has been cited by other articles:


Home page
 Eur J Cardiothorac SurgHome page
K. Takeuchi, S. Sakamoto, Y. Nagayoshi, H. Nishizawa, and J. Matsubara
Reactivity of the human internal thoracic artery to vasodilators in coronary artery bypass grafting
Eur J Cardiothorac Surg, November 1, 2004; 26(5): 956 - 959.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
G. Tavilla, N. H.J. Pijls, E. Berreklouw, and K. H. Peels
Noninvasive assessment of right gastroepiploic artery graft patency using transcutaneous color Doppler echocardiography
Ann. Thorac. Surg., March 1, 1999; 67(3): 624 - 628.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
F. L. Rosenfeldt, G.-W. He, B. F. Buxton, and J. A. Angus
Pharmacology of coronary artery bypass grafts
Ann. Thorac. Surg., March 1, 1999; 67(3): 878 - 888.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
R. Malhotra, H. S. Bedi, S. Bazaz, S. Jain, and N. Trehan
Morphometric Analysis of the Right Gastroepiploic Artery and the Internal Mammary Artery
Ann. Thorac. Surg., January 1, 1996; 61(1): 124 - 127.
[Abstract] [Full Text]

Home page
 CirculationHome page
C. A. Dietl, C. H. Benoit, C. L. Gilbert, E. L. Woods, W. F. Pharr, M. D. Berkheimer, N. P. Madigan, and F. J. Menapace
Which Is the Graft of Choice for the Right Coronary and Posterior Descending Arteries? : Comparison of the Right Internal Mammary Artery and the Right Gastroepiploic Artery
Circulation, November 1, 1995; 92(9): 92 - 97.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
S. S. Kushwaha, M. Bustami, S. Tadjkarimi, C. D. J. Ilsley, A. G. Mitchell, and M. H. Yacoub
LATE ENDOTHELIAL FUNCTION OF FREE AND PEDICLED INTERNAL MAMMARY ARTERY GRAFTS
J. Thorac. Cardiovasc. Surg., August 1, 1995; 110(2): 453 - 462.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1991 by The Society of Thoracic Surgeons.