HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Munetaka Masuda Marc Hendrikx Willem Flameng Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Masuda, M. Articles by Flameng, W. Search for Related Content PubMed PubMed Citation Articles by Masuda, M. Articles by Flameng, W.

Ann Thorac Surg 1991;52:1300-1305
© 1991 The Society of Thoracic Surgeons

---

Articles

Cardioprotective effects of nucleoside transport inhibition in rabbit hearts

^a Laboratory of Experimental Cardiac Surgery, Katholieke Universiteit Leuven, Leuven Belgium
^b Janssen Research Foundation, Beerse, Belgium

Accepted for publication July 17, 1991.

^_* Address reprint requests to Dr Flameng, Center of Experimental Surgery and Anesthesiology, Katholieke University Leuven, Provisorium 1, Minderbroedersstraat 17, 3000 Leuven, Belgium.

The cardioprotective effects of a nucleoside transport inhibitor, R75231, were investigated in the isolated rabbit heart. The hearts were subjected to 20 minutes of global normothermic ischemia followed by reperfusion. Before ischemia either solvent (group 1), 5 µmol/L of adenosine (group 2), or 0.64 mg/L R75231 (group 3) was added to the perfusate. Preischemic hemodynamics were not changed by treatment, except for an increase in coronary flow in the adenosine group (126% of control; p < 0.05). Upon reperfusion, coronary flow was depressed in the controls (72% of the preischemic control values), increased in the adenosine group (113%) and unchanged in the R75231 group (89%). Functional recovery was significantly better in the adenosine group as well as in the R75231 group as compared with the controls (p < 0.05). Cardiac output was 74% of the preischemic control value in the R75231 group, 67% in the adenosine group, and only 38% in the controls. Analysis of the coronary effluent after reperfusion showed a significant inhibition of rapid release of purines and a reverse of the adenosine/inosine ratio in the R75231 group as compared with the others. We conclude that R75231 has a cardioprotective effect that is probably related to accumulation of endogenous adenosine.

This article has been cited by other articles:

				Z. Zhu, P. A. Hofmann, and J. K. Buolamwini Cardioprotective effects of novel tetrahydroisoquinoline analogs of nitrobenzylmercaptopurine riboside in an isolated perfused rat heart model of acute myocardial infarction Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2921 - H2926. [Abstract] [Full Text] [PDF]

				H. T. Sommerschild, F. Grund, J. Offstad, P. Jynge, A. Ilebekk, and K. A. Kirkeboen Importance of Endogenous Adenosine During Ischemia and Reperfusion in Neonatal Porcine Hearts Circulation, November 4, 1997; 96(9): 3094 - 3103. [Abstract] [Full Text]