ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Charles E. Hobson
Barry Chan
Irving L. Kron
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hobson, C. E.
Right arrow Articles by Kron, I. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hobson, C. E.
Right arrow Articles by Kron, I. L.

Ann Thorac Surg 1991;52:1295-1299
© 1991 The Society of Thoracic Surgeons

Articles

Denervation of transplanted porcine lung causes airway obstruction

Charles E. Hobson, MD, W.Gerald Teague, MD, Curtis G. Tribble, MD, Stacey E. Mills, MD, Barry Chan, MD, Jon Agee, MD, Terry L. Flanagan, MPH, Irving L. Kron, MD*

Departments of Surgery, Pediatrics, and Pathology, University of Virginia School of Medicine, Charlottesville, Virginia USA

Accepted for publication July 16, 1991.

* Address reprint requests to Dr Kron, Department of Surgery, University of Virginia Health Sciences Center, Box 181, Charlottesville, VA 22908 USA.

Lung transplantation can be complicated by a form of small airway obstruction known as bronchiolitis obliterans. We tested the hypothesis that lung denervation causes small airway obstruction in young pigs (10 ± 1 weeks). Control pigs had an innervated native lobe, and study pigs had either a denervated native lobe or a denervated transplant lobe. Transplanted pigs received standard immunosuppression. At 10 weeks we measured isolated left lobe pulmonary mechanics. Dynamic resistance in both study groups was significantly higher than in the lobectomy group, whereas dynamic compliance in both study groups was significantly lower than in the lobectomy group. No significant difference in resistance or compliance was noted between the transplant and reimplant groups. Histologic changes consistent with rejection were noted in the transplant lobes. We conclude that the small airway obstruction noted in this model is due to operative denervation rather than to immunosuppression or rejection.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
R. ARENS, J. M. McDONOUGH, H. ZHAO, N. P. BLUMENTHAL, R. M. KOTLOFF, and M. M. GRUNSTEIN
Altered Lung Mechanics after Double-Lung Transplantation
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(5): 1403 - 1409.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. W. Carver Jr., S. K. Srinathan, C. R. Velloff, and J. Julio Perez Fontan
Increased Type I Procollagen mRNA in Airways and Pulmonary Vessels after Vagal Denervation in Rats
Am. J. Respir. Cell Mol. Biol., December 1, 1997; 17(6): 691 - 701.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1991 by The Society of Thoracic Surgeons.