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The Annals of Thoracic Surgery, Vol 52, 1158-1160, Copyright © 1991 by The Society of Thoracic Surgeons

ARTICLES

Propranolol for intractable hemolysis after open heart operation

Y Okita, S Miki, K Kusuhara, Y Ueda, T Tahata and K Yamanaka
Department of Cardiovascular Surgery, Tenri Hospital, Japan.

Postoperative intravascular hemolysis occurring in 2 patients was alleviated by propranolol. One patient underwent mitral valve replacement and had development of intractable hemolysis due to a paravalvular leak. The other patient underwent ventricular septal defect closure and had hemolysis caused by the Dacron patch. Both patients were given oral propranolol, and the degree of hemolysis decreased substantially. Although the exact mechanism of the propranolol effect on mechanical intravascular hemolysis is unclear, propranolol is thought to reduce the shearing stress between erythrocytes and the foreign material by slowing the velocity of the circulation.


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Copyright © 1991 by The Society of Thoracic Surgeons.