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The Annals of Thoracic Surgery, Vol 52, 1113-1120, Copyright © 1991 by The Society of Thoracic Surgeons
TM Egan, CJ Lambert Jr, R Reddick, KS Ulicny Jr, BA Keagy and BR Wilcox
A shortage of suitable donors is a serious obstacle to the widespread
application of isolated lung transplantation for end-stage lung disease. We
hypothesized that lung tissue likely remains viable for a sufficient period
of time to allow for safe postmortem retrieval of lungs for
transplantation. Studies were conducted in a nonsurvival model of canine
lung allotransplantation. Donor animals were sacrificed, and subsequent
lung harvest was delayed for 1 hour, 2 hours, or 4 hours. Pulmonary
retrieval was then performed in a standard fashion, flushing the lung block
with modified Euro-Collins solution. Lungs were then stored for 4 hours
before single allotransplantation. Recipient animals were maintained
anesthetized, and followed up for 8 hours. By occlusion of the pulmonary
artery and bronchus to the native lung, recipient animals were forced to
survive solely on the transplanted lung, with a constant inspired oxygen
fraction of 0.40. All 5 recipient animals of 1-hour cadaver lungs survived
the 8-hour observation period with excellent hemodynamics and gas exchange.
Two of 5 recipients of 2-hour cadaver lungs survived the observation
period, whereas a third animal survived for 5 hours with excellent gas
exchange. One of 4 animals transplanted with a 4-hour cadaver lung survived
the observation period. Retrieval of lungs from cadavers whose hearts are
not beating may prove to be a safe and effective method to increase the
pulmonary donor pool.
ARTICLES
A strategy to increase the donor pool: use of cadaver lungs for transplantation
Division of Cardiothoracic Surgery, University of North Carolina School of Medicine, Chapel Hill.
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D. E. M. Van Raemdonck, N. C. P. Jannis, F. R. L. Rega, P. R. J. De Leyn, W. J. Flameng, and T. E. Lerut Extended Preservation of Ischemic Pulmonary Graft by Postmortem Alveolar Expansion Ann. Thorac. Surg., September 1, 1997; 64(3): 801 - 808. [Abstract] [Full Text]
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S. Murakami, E. A. Bacha, P. Herve, H. Detruit, A. R. Chapelier, P. G. Dartevelle, and G.-M. Mazmanian Prevention of Reperfusion Injury by Inhaled Nitric Oxide in Lungs Harvested From Non-Heart-Beating Donors Ann. Thorac. Surg., December 1, 1996; 62(6): 1632 - 1638. [Abstract] [Full Text]
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A. M. D'Armini, J. J. Lemasters, and T. M. Egan Studies of Rat Lung Viability and Adenine Nucleotide Metabolism After Death Ann. Thorac. Surg., November 1, 1996; 62(5): 1448 - 1453. [Abstract] [Full Text]
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C. S. Roberts, A. M. D'Armini, and T. M. Egan CANINE DOUBLE-LUNG TRANSPLANTATION WITH CADAVERIC DONORS J. Thorac. Cardiovasc. Surg., September 1, 1996; 112(3): 577 - 583. [Abstract] [Full Text]
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D. E. M. Van Raemdonck, N. C. P. Jannis, F. R. L. Rega, P. R. J. De Leyn, W. J. Flameng, and T. E. Lerut Delay of Adenosine Triphosphate Depletion and Hypoxanthine Formation in Rabbit Lung After Death Ann. Thorac. Surg., July 1, 1996; 62(1): 233 - 240. [Abstract] [Full Text]
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R. J. Novick, K. E. Gehman, I. S. Ali, and J. Lee Lung Preservation: The Importance of Endothelial and Alveolar Type II Cell Integrity Ann. Thorac. Surg., July 1, 1996; 62(1): 302 - 314. [Abstract] [Full Text]
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S. A. Buchanan, N. F. DeLima, O. A. R. Binns, M. C. Mauney, J. T. Cope, S. E. Langenburg, K. S. Shockey, J. D. Bianchi, V. I. Parekh, C. G. Tribble, et al. Pulmonary Function After Non-Heart-Beating Lung Donation in a Survival Model Ann. Thorac. Surg., July 1, 1995; 60(1): 38 - 44. [Abstract] [Full Text]
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Y. Umemori, H. Date, K. Uno, M. Aoe, A. Ando, and N. Shimizu Improved Lung Function by Urokinase Infusion in Canine Lung Transplantation Using Non-Heart-Beating Donors Ann. Thorac. Surg., June 1, 1995; 59(6): 1513 - 1518. [Abstract] [Full Text]
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T. M. Egan, F. C. Detterbeck, M. R. Mill, L. J. Paradowski, R. P. Lackner, W. D. Ogden, J. R. Yankaskas, J. H. Westerman, J. T. Thompson, M. A. Weiner, et al. Improved results of lung transplantation for patients with cystic fibrosis J. Thorac. Cardiovasc. Surg., February 1, 1995; 109(2): 224 - 235. [Abstract] [Full Text]
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