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Ann Thorac Surg 1991;52:245-249
© 1991 The Society of Thoracic Surgeons

Articles

Preliminary results of left heart bypass in pigs using a heparin-coated centrifugal pump

C. Campanella, MD, FRCSEd*, E. Cameron, FRCSEd, C. Sinclair, FFARCS, V.L. Feilberg, MD, C. Hider, FFARCS, S. Prasad, FRCSEd, F. Boulton, MD, FRCPath, D. Lamb, FRCPath

Cardiac Surgical Unit, University of Edinburgh Medical School, Edinburgh, Scotland

Accepted for publication April 12, 1991.

* Address reprint requests to Mr Campanella, Cardiac Surgery Unit, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, Scotland.

To assess the feasibility of left ventricular assist without systemic heparinization, we used a commercially available (Sarns 3M) centrifugal pump with tubing set and cannulas, all internally precoated for the purpose of this study with heparin, to bypass the left ventricle in 12 pigs for periods of either 1 or 3 hours. There was no significant activation of clotting and there was no sign of generalized embolization. However, on postmortem studies, 5 kidneys out of 22 examined showed signs of minimal thromboembolism. This experiment shows that artificial left ventricular assist, free of systemic heparinization but using heparin precoating, is feasible and safe, at least for a short period of time.




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J. D. Fonger, Y. Zhou, H. Matsuura, G. S. Aldea, and R. J. Shemin
Enhanced preservation of acutely ischemic myocardium with transseptal left ventricular assist
Ann. Thorac. Surg., March 1, 1994; 57(3): 570 - 575.
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