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Ann Thorac Surg 1991;52:74-77
© 1991 The Society of Thoracic Surgeons
a Carolinas Heart Institute at the Carolinas Medical Center and the Heineman Medical Research Laboratory, Charlotte, North Carolina USA
b The Department of Internal Medicine, College of Medium, University of South Florida, Tampa, Florida USA
Accepted for publication February 28, 1991.
* Address reprint requests to Dr Robicsek, Heineman Medical Research Center, PO Box 35457, Charlotte, NC 28235.
* Address reprint requests to Dr Robicsek, Heineman Medical Research Center, PO Box 35457, Charlotte, NC 28235.
Owing to similarities between human immunodeficiency virus and feline retrovirases, the feline model was chosen for the study to investigate the efficacy of timely topical treatment of accidental human immunodeficiency virus infection in the operating room. Cats were subcutaneously inoculated with either feline leukemia virus or feline immunodeficiency virus. An effort was made to neutralize the virus in loco either by infiltration of the inoculation site with povidone-iodine or with monoclonal antibodies, or by cauterization and excision. The animals were periodically monitored for feline leukemia virus antigens or for feline immunodeficiency virus antibodies. The results indicated that in the feline model, the development of generalized virus infection may be prevented by local measures if applied immediately.
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