| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1991;52:46-50
© 1991 The Society of Thoracic Surgeons
Surgery Branch, National Heart, Lung, and Blood Institute, and Molecular, Cellular and Nutritional Endocrinology Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland USA
* Address reprint requests to Dr Clark, Cardiovascular/Pulmonary Research Center, Allegheny-Singer Research Institute, 320 E North Ave, Pittsburgh, PA 15212.
The purpose of this prospective study was to define the effect of cardiopulmonary bypass on the concentrations of thyroid hormones and metabolites. Blood samples were obtained from 14 patients preoperatively, at specific times throughout cardiopulmonary bypass, and serially to 24 hours postoperatively. Thyroid-stimulating hormone, thyroid-binding globulin, total thyroxine, triiodothyronine (T3), and reverse T3, an inactive metabolite of thyroxine, were measured by radioimmunoassay. Free T3 was assayed by equilibrium dialysis. Values of total T3 and free T3, the active hormone, were significantly depressed (75% and 50%, respectively) up to 24 hours after bypass (p < 0.05). Reverse T3 demonstrated a greater than fourfold rise at 8 and 24 hours postoperatively (p < 0.05). Thyroid-binding globulin was decreased at all sampling times (p < 0.05). Thyroid-stimulating hormone, thyroxine, and free thyroxine levels remained within normal ranges at all sampling times. These results indicate that cardiopulmonary bypass simulates the "euthyroid sick syndrome" as seen in severely burned patients and critically ill patients, which is characterized by depression of T3 and free T3 concentrations with a concomitant increase in reverse T3 levels and normal concentrations of thyroid-stimulating hormone, thyroxine, and free thyroxine. The hemodynamic effects of primary hypothyroidism are well established. These data provide further support for investigational trials of intravenous administration of T3 in the prevention or treatment of low cardiac output syndrome after cardiopulmonary bypass.
This article has been cited by other articles:
|
|
 |
|
  M. A. Hassan Talukder, F. Yang, Y. Nishijima, C.-A. Chen, L. Xie, S. D. Mahamud, A. Kalyanasundaram, J. D. Bonagura, M. Periasamy, and J. L. Zweier Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion Am J Physiol Heart Circ Physiol, February 1, 2011; 300(2): H702 - H711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Adawiyah, A. W. Norasyikin, N. H. Mat, A. S. Shamsul, and K. N. Azmi The non-thyroidal illness syndrome in acute coronary syndrome is associated with increased cardiac morbidity and mortality Heart Asia, January 1, 2010; 2(1): 11 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.P. Mehra, K.S. Shah, P.C. Jain, S.K. Bhansali, J.D. Sunawala, B.V. Gandhi, A. Oswal, and R.A. Karatela Combined Off-pump Coronary Artery Bypass Grafting and Thyroidectomy Ann. Thorac. Surg., August 1, 2009; 88(2): 661 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Velissaris, A. T. M. Tang, P. J. Wood, D. A. Hett, and S. K. Ohri Thyroid function during coronary surgery with and without cardiopulmonary bypass Eur J Cardiothorac Surg, July 1, 2009; 36(1): 148 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. I. Spratt, R. S. Kramer, J. R. Morton, F. L. Lucas, K. Becker, and C. Longcope Characterization of a prospective human model for study of the reproductive hormone responses to major illness Am J Physiol Endocrinol Metab, July 1, 2008; 295(1): E63 - E69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Olivares, M. P. Marassi, R. S. Fortunato, A. C. M. da Silva, R. H. Costa-e-Sousa, I. G. Araujo, E. C. Mattos, M. O. Masuda, M. A. Mulcahey, S. A. Huang, et al. Thyroid Function Disturbance and Type 3 Iodothyronine Deiodinase Induction after Myocardial Infarction in Rats A Time Course Study Endocrinology, October 1, 2007; 148(10): 4786 - 4792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. I. Spratt, M. Frohnauer, H. Cyr-Alves, R. S. Kramer, F. L. Lucas, J. R. Morton, D. F. Cox, K. Becker, and J. T. Devlin Physiological effects of nonthyroidal illness syndrome in patients after cardiac surgery Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E310 - E315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Ranasinghe, D. W. Quinn, D. Pagano, N. Edwards, M. Faroqui, T. R. Graham, B. E. Keogh, J. Mascaro, D. W. Riddington, S. J. Rooney, et al. Glucose-Insulin-Potassium and Tri-Iodothyronine Individually Improve Hemodynamic Performance and Are Associated With Reduced Troponin I Release After On-Pump Coronary Artery Bypass Grafting Circulation, July 4, 2006; 114(1_suppl): I-245 - I-250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ullah, L. Zabala, B. Watkins, and M. L Schmitz Cardiac organ donor management Perfusion, March 1, 2006; 21(2): 93 - 98. [Abstract] [PDF]
|
|
|
|
 |
|
 G. J. Kahaly and W. H. Dillmann Thyroid Hormone Action in the Heart Endocr. Rev., August 1, 2005; 26(5): 704 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sirlak, L. Yazicioglu, M. B. Inan, S. Eryilmaz, R. Tasoz, A. Aral, and U. Ozyurda Oral thyroid hormone pretreatment in left ventricular dysfunction Eur J Cardiothorac Surg, October 1, 2004; 26(4): 720 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fazio, E. A. Palmieri, G. Lombardi, and B. Biondi Effects of Thyroid Hormone on the Cardiovascular System Recent Prog. Horm. Res., January 1, 2004; 59(1): 31 - 50. [Abstract] [Full Text]
|
|
|
|
|
|
A. G. Cerillo, S. Bevilacqua, S. Storti, M. Mariani, E. Kallushi, A. Ripoli, A. Clerico, and M. Glauber Free triiodothyronine: a novel predictor of postoperative atrial fibrillation Eur J Cardiothorac Surg, October 1, 2003; 24(4): 487 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Iervasi, A. Pingitore, P. Landi, M. Raciti, A. Ripoli, M. Scarlattini, A. L'Abbate, and L. Donato Low-T3 Syndrome: A Strong Prognostic Predictor of Death in Patients With Heart Disease Circulation, February 11, 2003; 107(5): 708 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Cerillo, L. Sabatino, S. Bevilacqua, P. A. Farneti, M. Scarlattini, F. Forini, and M. Glauber Nonthyroidal illness syndrome in off-pump coronary artery bypass grafting Ann. Thorac. Surg., January 1, 2003; 75(1): 82 - 87. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Salenger, J. S. Gammie, and T. J. Vander Salm Postoperative Care of Cardiac Surgical Patients Card. Surg. Adult, January 1, 2003; 2(2003): 439 - 469. [Full Text]
|
|
|
|
 |
|
 C. J. O'Connor, R. March, and K. J. Tuman Severe Myxedema After Cardiopulmonary Bypass Anesth. Analg., January 1, 2003; 96(1): 62 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. U. Syed, A. F El Watidy, N B. Akhlaque, A. Wahba, R. M El Oakley, K. Imran, E. A Al Bukhari, and M. R Al Fagih Coronary Bypass Surgery in Patients on Thyroxin Replacement Therapy Asian Cardiovasc Thorac Ann, June 1, 2002; 10(2): 107 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L Stewart, N. Ssemakula, D. R MacMillan, L J. Goldsmith, and L. N Cook Thyroid function in neonates with severe respiratory failure on extracorporeal membrane oxygenation Perfusion, December 1, 2001; 16(6): 469 - 475. [Abstract] [PDF]
|
|
|
|
|
|
K. Ojamaa, A. Kenessey, R. Shenoy, and I. Klein Thyroid hormone metabolism and cardiac gene expression after acute myocardial infarction in the rat Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1319 - E1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Mainwaring, E. Capparelli, K. Schell, M. Acosta, and J. C. Nelson Pharmacokinetic Evaluation of Triiodothyronine Supplementation in Children After Modified Fontan Procedure Circulation, March 28, 2000; 101(12): 1423 - 1429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Mullis-Jansson, M. Argenziano, S. Corwin, S. Homma, A. D. Weinberg, M. Williams, E. A. Rose, and C. R. Smith A RANDOMIZED DOUBLE-BLIND STUDY OF THE EFFECT OF TRIIODOTHYRONINE ON CARDIAC FUNCTION AND MORBIDITY AFTER CORONARY BYPASS SURGERY J. Thorac. Cardiovasc. Surg., June 1, 1999; 117(6): 1128 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. V. DiPierro, J. E. Bavaria, E. B. Lankford, D. J. Polidori, M. A. Acker, J. T. Streicher, and T. J. Gardner Triiodothyronine Optimizes Sheep Ventriculoarterial Coupling for Work Efficiency Ann. Thorac. Surg., September 1, 1996; 62(3): 662 - 669. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Bennett-Guerrero, J. L. Jimenez, W. D. White, E. B. D'Amico, B. I. Baldwin, D. A. Schwinn, Duke T3 Study Group, N. P. Bouknight, C. M. Chuey, F. M. Clements, et al. Cardiovascular Effects of Intravenous Triiodothyronine in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized, Double-blind, Placebo-Controlled Trial JAMA, March 6, 1996; 275(9): 687 - 692. [Abstract] [PDF]
|
|
|
|
|
|
R. Scrofani, M. Salati, and C. Santoli Effect of cardiopulmonary bypass on thyroid function Ann. Thorac. Surg., May 1, 1995; 59(5): 1273 - 1274. [PDF]
|
|
|
|
|
|
J. D. Klemperer, J. Zelano, R. E. Helm, K. Berman, K. Ojamaa, I. Klein, O. W. Isom, and K. Krieger Triiodothyronine improves left ventricular function without oxygen wasting effects after global hypothermic ischemia J. Thorac. Cardiovasc. Surg., March 1, 1995; 109(3): 457 - 465. [Abstract] [Full Text]
|
|
|
|
|
|
B. Murzi, G. Iervasi, S. Masini, R. Moschetti, V. Vanini, G. Zucchelli, and A. Biagini Thyroid hormones homeostasis in pediatric patients during and after cardiopulmonary bypass Ann. Thorac. Surg., February 1, 1995; 59(2): 481 - 485. [Abstract] [PDF]
|
|
|
|
|
|
J. D. Walker, F. A. Crawford Jr, R. Mukherjee, M. R. Zile, and F. G. Spinale Direct effects of acute administration of 3, 5, 3' triiodo-L-thyronine on myocyte function Ann. Thorac. Surg., September 1, 1994; 58(3): 851 - 856. [Abstract] [PDF]
|
|
|
|
|
|
T. H. Jones, S. M. Hunter, A. Price, and G. D. Angelini Should thyroid function be assessed before cardiopulmonary bypass operations? Ann. Thorac. Surg., August 1, 1994; 58(2): 434 - 436. [Abstract] [PDF]
|
|
|
|
|
|
S. Buket, A. Alayunt, M. Ozbaran, A. Hamulu, B. Discigil, B. Cetindag, H. Ozkilic, Z. Balkan, O. Bilkay, and I. Durmaz Effect of pulsatile flow during cardiopulmonary bypass on thyroid hormone metabolism Ann. Thorac. Surg., July 1, 1994; 58(1): 93 - 96. [Abstract] [PDF]
|
|
|
|
|
|
C. M. Dyke, M. Ding, A. S. Abd-Elfattah, K. Loesser, R. J. Dignan, A. S. Wechsler, and D. R. Salter Effects of triiodothyronine supplementation after myocardial ischemia Ann. Thorac. Surg., August 1, 1993; 56(2): 215 - 222. [Abstract] [PDF]
|
|
|
|
|
|
E. Sypniewski Comparative pharmacology of the thyroid hormones Ann. Thorac. Surg., July 1, 1993; 56(1_suppl_1): S2 - S8. [Abstract] [PDF]
|
|
|
|
|
|
R. E. Clark Cardiopulmonary bypass and thyroid hormone metabolism Ann. Thorac. Surg., July 1, 1993; 56(1_suppl_1): S35 - S42. [Abstract] [PDF]
|
|
|
|
|
|
M. A. Hamilton Prevalence and clinical implications of abnormal thyroid hormone metabolism in advanced heart failure Ann. Thorac. Surg., July 1, 1993; 56(1_suppl_1): S48 - S53. [Abstract] [PDF]
|
|
|
|
|
|
S. W. Downing and L. H. Edmunds Jr Release of vasoactive substances during cardiopulmonary bypass Ann. Thorac. Surg., December 1, 1992; 54(6): 1236 - 1243. [Abstract] [PDF]
|
|
|
|
|
|
F. W. Holland II, P. S. Brown Jr, and R. E. Clark Acute severe postischemic myocardial depression reversed by triiodothyronine Ann. Thorac. Surg., August 1, 1992; 54(2): 301 - 305. [Abstract] [PDF]
|
|
|
|
|
|
C. M. Dyke, T. Yeh Jr, J. D. Lehman, A. Abd-Elfattah, M. Ding, A. S. Wechsler, and D. R. Salter Triiodothyronine-enhanced left ventricular function after ischemic injury Ann. Thorac. Surg., July 1, 1991; 52(1): 14 - 19. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
