HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Olak, J. Articles by Brown, E. Search for Related Content PubMed PubMed Citation Articles by Olak, J. Articles by Brown, E.

The Annals of Thoracic Surgery, Vol 51, 956-958, Copyright © 1991 by The Society of Thoracic Surgeons

ARTICLES

Randomized trial of one-dose versus six-dose cefazolin prophylaxis in elective general thoracic surgery

J Olak, K Jeyasingham, C Forrester-Wood, J Hutter, M al-Zeerah and E Brown
Frenchay Hospital, Bristol, United Kingdom.

The objective of this study was to compare the efficacy of one to six doses of cefazolin as prophylaxis in general thoracic surgery using a randomized, double-blind design. Two-hundred eight consecutive patients admitted to a regional thoracic surgery unit for elective thoracotomy and lung resection were eligible for the trial. There were no wound infections in the one-dose group and two in the six-dose group (95% confidence intervals [CI]: -0.008, +0.048 [The positive number refers to the largest possible difference in favor of the one-dose group and the negative number, the largest possible difference in favor of the six-dose group]). Each group had eight postoperative chest infections (CI: -0.075, +0.077) and three empyemas (CI: -0.004, +0.050). Thirty- day mortality was 5% in the one-dose group and 4% in the six-dose group (CI: -0.053, +0.069). Postoperative duration of hospital stay, requirement for antibiotics, and the need for reoperation were comparable. These results suggest that six doses of cefazolin do not confer clinically important benefit beyond that obtained from a single dose for prophylaxis of wound infection in elective general thoracic surgery.

This article has been cited by other articles:

				D. M. Radu, F. Jaureguy, A. Seguin, C. Foulon, M. D. Destable, J. Azorin, and E. Martinod Postoperative Pneumonia After Major Pulmonary Resections: An Unsolved Problem in Thoracic Surgery Ann. Thorac. Surg., November 1, 2007; 84(5): 1669 - 1673. [Abstract] [Full Text] [PDF]

				O. Schussler, M. Alifano, H. Dermine, S. Strano, A. Casetta, S. Sepulveda, A. Chafik, S. Coignard, A. Rabbat, and J.-F. Regnard Postoperative Pneumonia after Major Lung Resection Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1161 - 1169. [Abstract] [Full Text] [PDF]

				D. N. Nan, M. Fernandez-Ayala, C. Farinas-Alvarez, R. Mons, F. J. Ortega, J. Gonzalez-Macias, and M. C. Farinas Nosocomial Infection After Lung Surgery: Incidence and Risk Factors Chest, October 1, 2005; 128(4): 2647 - 2652. [Abstract] [Full Text] [PDF]

				M.L. Rogers, R. Taylor, and F.D. Beggs Antibiotic prophylaxis in general thoracic surgery in the UK Eur. J. Cardiothorac. Surg., September 1, 2000; 18(3): 375 - 376. [Full Text] [PDF]

				J. Boldt, S. Piper, D. Uphus, R. Fussle, and G. Hempelmann Preoperative microbiologic screening and antibiotic prophylaxis in pulmonary resection operations Ann. Thorac. Surg., July 1, 1999; 68(1): 208 - 211. [Abstract] [Full Text] [PDF]

				A. Bernard, M. Pillet, P. Goudet, and H. Viard Antibiotic prophylaxis in pulmonary surgeryA prospective randomized double-blind trial of flash cefuroxime versus forty-eight-hour cefuroxime J. Thorac. Cardiovasc. Surg., March 1, 1994; 107(3): 896 - 900. [Abstract] [Full Text]