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Ann Thorac Surg 1991;51:833-836
© 1991 The Society of Thoracic Surgeons

Articles

Agglutination of blood cardioplegia by cold reacting autoantibodies

William L. Holman, MD*, Shirley H. Smith, MD, Rosemary Edwards, MD, Shu T. Huang, MD

Division of Cardiothoracic Surgery and Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama USA

Accepted for publication October 23, 1990.

* Address reprint requests to Dr Holman, Department of Surgery, University Station, Birmingham, AL 35294.

Cold-reacting autoantibodies occasionally occur in patients requiring cardiac operations. This report describes the clinical course of 1 patient with cold-reacting autoantibodies and intracoronary agglutination of the blood cardioplegia solution. Observations made in vivo and in vitro are considered in discussing recommendations for the management of extracorporeal circulation and cardioplegic arrest in patients with clinically silent cold-reacting autoantibodies.




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