HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Yasunori Watanabe Katsuo Fuse Toshio Konishi Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Watanabe, Y. Articles by Shibata, Y. Search for Related Content PubMed PubMed Citation Articles by Watanabe, Y. Articles by Shibata, Y.

Ann Thorac Surg 1991;51:767-772
© 1991 The Society of Thoracic Surgeons

---

Articles

Autologous blood transfusion with recombinant human erythropoietin in heart operations

Division of Cardiovascular Surgery and Immunohematology, Toranomon Hospital, Tokyo, Japan

Accepted for publication February 5, 1991.

^_* Address reprint requests to Dr Watanabe, Division of Cardiovascular Surgery, Toranomon Hospital, 2-2-2, Toranomon, Minato-ku, Tokyo, 105 Japan.

The effects of recombinant human erythropoietin (rHuEPO) on improving the anemia associated with autologous blood collection before open heart operations and on improving the postoperative anemia were studied. The study was carried out on 18 patients undergoing coronary artery bypass operations; 400 mL of autologous whole blood was taken from each patient 2 weeks before operation and was subsequently used in the operation, and rHuEPO (100 U · kg^–1 day^–1) was given intravenously for 2 weeks before operation and for 1 week after operation. The group in which iron preparations were also administered intravenously was designated as group I (10 patients), and the group in which rHuEPO was given alone was designated as group II (8 patients). In group III, as a control group, 11 past patients were used in whom 400 mL of autologous whole blood was collected 2 weeks before operation but neither rHuEPO nor iron preparations were given. After autologous blood collections, the hemoglobin levels improved in group I, group II, and group III, in that order, and with significant differences among them. It was shown that rHuEPO was effective in ameliorating the anemia associated with preoperative autologous blood collection, and the effect was further enhanced with intravenous supplementing iron preparations. After operation, the anemia markedly improved while rHuEPO was administered, but the hemoglobin levels decreased rapidly when the administration was terminated. Further studies are needed regarding the use of rHuEPO after operation.

This article has been cited by other articles:

				H. D. Golab, J. J. Takkenberg, and A. J. Bogers Specific requirements for bloodless cardiopulmonary bypass in neonates and infants; a review Perfusion, July 1, 2010; 25(4): 237 - 243. [Abstract] [PDF]

				L. YazicioGlu, S. Eryilmaz, M. Sirlak, M. B. Inan, A. Aral, R. Tasoz, N. T. Eren, B. Kaya, and H. Akalin Recombinant human erythropoietin administration in cardiac surgery J. Thorac. Cardiovasc. Surg., October 1, 2001; 122(4): 741 - 745. [Abstract] [Full Text] [PDF]

				M H Cross Autotransfusion in cardiac surgery Perfusion, September 1, 2001; 16(5): 391 - 400. [Abstract] [PDF]

				H. Urayama, H. Ohtake, K. Tawaraya, and Y. Watanabe Autologous Blood Donation with Erythropoietin in Abdominal Aortic Aneurysm Repair: Special Reference to Blood Pressure and Hormonal Changes Vascular and Endovascular Surgery, March 1, 2000; 34(2): 157 - 162. [Abstract] [PDF]

				L. T. Goodnough, G. J. Despotis, and C. A. Parvin Erythropoietin Therapy in Patients Undergoing Cardiac Operations Ann. Thorac. Surg., December 1, 1997; 64(6): 1579 - 1580. [Full Text]

				M. N. D'Ambra, R. J. Gray, R. Hillman, J. W. Jones, H. C. Kim, R. Rawitscher, H. Schnaper, I. Szymanski, G. J. Vlahakes, D. Kaplan, et al. Effect of Recombinant Human Erythropoietin on Transfusion Risk in Coronary Bypass Patients Ann. Thorac. Surg., December 1, 1997; 64(6): 1686 - 1693. [Abstract] [Full Text]

				M. Cazzola, F. Mercuriali, and C. Brugnara Use of Recombinant Human Erythropoietin Outside the Setting of Uremia Blood, June 15, 1997; 89(12): 4248 - 4267. [Full Text] [PDF]

				Y. Sakakibara, Y. Kaminishi, and S. Mitsuhashi Coronary Artery Bypass in a Patient With Pernicious Anemia Ann. Thorac. Surg., January 1, 1997; 63(1): 303 - 303. [Full Text]

				L. Sandrelli, A. Pardini, R. Lorusso, M. L. Sala, M. Licenziati, and O. Alfieri Impact of autologous blood predonation on a comprehensive blood conservation program Ann. Thorac. Surg., March 1, 1995; 59(3): 730 - 735. [Abstract] [PDF]

				T. Konishi, T. Ohbayashi, T. Kaneko, T. Ohki, Y. Saitou, and Y. Yamato Preoperative use of erythropoietin for cardiovascular operations in anemia Ann. Thorac. Surg., July 1, 1993; 56(1): 101 - 103. [Abstract] [PDF]

				W. H. Dzik, A. G. Fleisher, D. Ciavarella, K. J. Karison, G. E. Reed, and R. L. Berger Safety and efficacy of autologous blood donation before elective aortic valve operation Ann. Thorac. Surg., December 1, 1992; 54(6): 1177 - 1180. [Abstract] [PDF]

				Y. Watanabe, K. Fuse, Y. Naruse, T. Kobayashi, S. Yamamoto, H. Konishi, T. Horii, and Y. Shibata Subcutaneous use of erythropoietin in heart surgery Ann. Thorac. Surg., September 1, 1992; 54(3): 479 - 484. [Abstract] [PDF]

				L. Tim Goodnough and A. Geha A new era in blood conservation Ann. Thorac. Surg., May 1, 1991; 51(5): 703 - 704. [PDF]