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Neal D. Kon
Michael H. Hines
Charles D. Harr
Stephen A. Mills
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Ann Thorac Surg 1991;51:557-562
© 1991 The Society of Thoracic Surgeons

Articles

Improved lung preservation with cold air storage

Neal D. Kon, MD*, Michael H. Hines, MD, Charles D. Harr, MD, Larry R. Miller, PhD, MD, Carol L. Taylor, MAS, A.Robert Cordell, MD, Stephen A. Mills, MD

Departments of Cardiothoracic Surgery and Pathology, The Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina USA

* Address reprint requests to Dr Kon, Department of Cardiothoracic Surgery, 300 South Hawthorne Rd, Winston-Salem, NC 27103.

Conventional topical slush cooling limits lung transport to 4 to 6 hours. For this canine study of an alternate air cooling system, 37 canine lungs were removed: 24 were placed in plastic bags, and inserted in a Transplanthermm container at core air temperatures (n = 6 lungs each) of (A) 4 °C, (B) 8 °C, (C) 12 °C, and (D) 20 °C; 6 were stored conventionally in ice slush (E); and 7 were transplanted immediately (F). After 8 hours, the stored lungs were transplanted and the contralateral pulmonary artery was ligated. Survival, arterial oxygen tension, and extravascular lung water were monitored at 15 minutes and every hour for 4 hours. Four-hour survival was 100% in groups A, B, and F; 83% in group C, 50% in group D, and 17% in group E. The mean arterial oxygen tension at 1 hour was lower in group E (6.4 ± 2.4 kPa) than in group A (39.8 ± 13.2 kPa) (p = 0,0002) or in group F (42.0 ± 16.2 kPa) (p = 0.0035). Extravascular lung water in group E was higher at 15 minutes (15.44 ± 5.63 mL/kg) than in group A (3.76 ± 0.63 mL/kg) (p = 0.0001) and group F (4.69 ± 1.65 mL/kg) (p = 0.003). Cold air storage appears to provide better lung preservation than hypothermic immersion in ice slush.






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Copyright © 1991 by The Society of Thoracic Surgeons.