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Ann Thorac Surg 1990;50:575-578
© 1990 The Society of Thoracic Surgeons

Articles

Long-term amiodarone administration protects against global myocardial ischemia

James A. Karlson, MD, MMSc*, Robert W. Hopkins, MD, John M. Moran, MD, Karl E. Karlson, MD, PhD

Brown University, Providence, Rhode Island USA

Accepted for publication May 3, 1990.

* Address reprint requests to Dr Karlson, 110 Lockwood St, Providence, RI 02903.

Reports on the effects of amiodarone on cardiac function have been variable. This study addresses the effect of long-term amiodarone administration on recovery of cardiac function after a period of global ischemia. Normotensive and spontaneously hypertensive rats were used. Normotensive rats (n = 6) received 240 mg/kg amiodarone for 4 weeks, for a total of 72 ± 3 mg. Hypertensive rats (n = 6) received 500 mg/kg amiodarone for 4 weeks, for a total of 116 ± 5 mg. Final myocardial concentrations of amiodarone and desethylamiodarone were 1.85 ± 1.75 and 0.50 ± 0.61 µg/g wet weight for the normotensive rats and 1.30 ± 0.58 and 0.31 ± 0.17 µg/g for the hypertensive rats (p = nonsignificant). Equal numbers of controls received sterile saline solution for 4 weeks. The hearts were excised and perfused in a Langendorff apparatus. The results indicate that, after 15 minutes of normothermic ischemia, hearts treated with this relatively low dose of amiodarone recovered a greater percentage of preischemic work (97% ± 13%) as compared with the controls (76% ± 17%) (p < 0.005).






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