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The Annals of Thoracic Surgery, Vol 50, 534-538, Copyright © 1990 by The Society of Thoracic Surgeons
E Pescarmona, EA Rendina, F Venuta, E D'Arcangelo, M Pagani, C Ricci, LP Ruco and CD Baroni
The prognostic value of four clinical variables (age and sex of patients,
association with myasthenia gravis, and clinical stage) and histological
type was analyzed in 83 consecutive patients with thymoma, histologically
classified as cortical, medullary, and mixed. Age, sex, and association
with myasthenia gravis did not prove to represent significant prognostic
factors; clinical stage and histological type, on the contrary, had a
highly significant prognostic value (p less than 0.001). A model of
clinicopathological staging, based on both clinical stage and histological
type, in which three major prognostic groups are considered is proposed.
The degree of significance of this model is higher (p less than 0.0001)
than that of clinical stage and histological type considered individually;
its validity is further supported by the results of multivariate analysis
according to the Cox regression model (p = 0.0001). We think it represents
a prognostically valuable approach to the problem of management of thymoma.
ARTICLES
Analysis of prognostic factors and clinicopathological staging of thymoma
II Department of Pathological Anatomy, University of Rome, La Sapienza, Italy.
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