HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Jan L. Svennevig Erik Fosse Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Svennevig, J. L. Search for Related Content PubMed PubMed Citation Articles by Svennevig, J. L.

Ann Thorac Surg 1990;50:387-391
© 1990 The Society of Thoracic Surgeons

---

Articles

Complement activation with bubble and membrane oxygentors in aortocorpnary bypass grafting

Vibeke Videm, MD^_*,a,b, Erik Fosse, MD, PhD^a,b, Tom Eirik Mollnes, MD, PhD^a,b, Peter Garred, MD^a,b with technical assistance from Hans Nielsen

^a Institute for Experimental Medical Research and Surgical Department, Ullevaal Hospital, University of Oslo, Oslo, Norway
^b Institute of Immunology and Rheumatology, The National Hospital, University of Oslo, Oslo, Norway

Accepted for publication March 26, 1990.

^_* Address reprint requests to Dr Videm, Institute for Experimental Medical Research, University of Oslo, Ullevaal Hospital, N-0407 Oslo 4 Norway.

Thirty-three patients admitted for coronary bypass grafting were randomized to cardiopulmonary bypass with a bubble oxygenator (Cobe or Polystan) or a membrane oxygenator (SciMed). Plasma concentrations of C3 activation products and the terminal complement complex were measured using enzyme immunoassays. Both variables increased almost linearly after onset of cardiopulmonary bypass, with maximal concentrations at clossure of the sternum. From a baseline of 7.5 to 12.0 arbitrary units (AU)/mL (medians), the concentrations of C3 activation products increased by 117.5 AU/mL (Cobe), 120.5 AU/mL (Polystan), and 213.3 AU/mL (SciMed). The increase in the membrane group was significantly higher than in the two bubble oxygenator groups (p < 0.01). From a baseline of 0.9 to 1.3 AU/mL, the concentrations of terminal complement complex increased by 5.4 AU/mL (Cobe), 6.6 AU/mL (Polystan), and 7.7 AU/mL (SciMed) (differences not significant). The higher C3 activation caused by the membrane oxygenator may be explained by differences in flow profile and surface area in contact with blood. The study cannot confirm the general assumption that membrane oxygenators lead to lower complement activation than do bubble oxygenators.

This article has been cited by other articles:

				T. N Hoel, V. Videm, S. T Baksaas, T. E Mollnes, F. Brosstad, and J. L Svennevig Comparison of a Duraflo II-coated cardiopulmonary bypass circuit and a trillium-coated oxygenator during open-heart surgery Perfusion, May 1, 2004; 19(3): 177 - 184. [Abstract] [PDF]

				M. Flynn, S. Reddy, W. Shepherd, C. Holmes, D. Armstrong, C. Lunn, K. Khan, and S. Kendall Fast-tracking revisited: routine cardiac surgical patients need minimal intensive care Eur J Cardiothorac Surg, January 1, 2004; 25(1): 116 - 122. [Abstract] [Full Text] [PDF]

				R. D. Riley, H. Sato, Z.-Q. Zhao, V. H. Thourani, J. E. Jordan, A. X. Fernandez, X.-L. Ma, D. R. Hite, D. F. Rigel, T. C. Pellas, et al. Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization J. Thorac. Cardiovasc. Surg., August 1, 2000; 120(2): 350 - 358. [Abstract] [Full Text] [PDF]

				M. Tofukuji, C. Metais, C. D. Collard, D. S. Morse, G. L. Stahl, D. P. Nelson, J. Li, M. Simons, and F. W. Sellke Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pig Ann. Thorac. Surg., January 1, 1999; 67(1): 112 - 119. [Abstract] [Full Text] [PDF]

				R de Vroege, P M. Rutten, C Kalkman, T A Out, P G. Jansen, L Eijsman, B J. de Mol, and C R. Wildevuur Biocompatibility of three different membrane oxygenators: effects on complement, neutrophil and monocyte activation Perfusion, December 1, 1997; 12(6): 369 - 375. [Abstract] [PDF]

				J. Svennevig, S. Tollofsrud, U. Kongsgaard, H. Noddeland, B. Mohr, M. Ozer, and T. Mollnes Complement activation during and after open-heart surgery is only marginally affected by the choice of fluid for volume replacement Perfusion, January 1, 1996; 11(4): 326 - 332. [Abstract] [PDF]

				N. E. Moat, N. Rebuck, D. F. Shore, T. W. Evans, and A. H. R. Finn Humoral and cellular activation in a simulated extracorporeal circuit Ann. Thorac. Surg., December 1, 1993; 56(6): 000349759390742Z - 349759390742Z. [Abstract] [PDF]

				A. M. Gillinov, P. A. DeValeria, J. A. Winkelstein, I. Wilson, W. E. Curtis, D. Shaw, C. G. Yeh, A. R. Rudolph, W. A. Baumgartner, A. Herskowitz, et al. Complement inhibition with soluble complement receptor type 1 in cardiopulmonary bypass Ann. Thorac. Surg., March 1, 1993; 55(3): 619 - 624. [Abstract] [PDF]

				J. Butler, G. M. Rocker, and S. Westaby Inflammatory response to cardiopulmonary bypass Ann. Thorac. Surg., February 1, 1993; 55(2): 552 - 559. [Abstract] [PDF]

				V. Videm, E. Fosse, T. E. Mollnes, P. Garred, and J. L. Svennevig Time for new concepts about measurement of complement activation by cardiopulmonary bypass? Ann. Thorac. Surg., October 1, 1992; 54(4): 725 - 731. [Abstract] [PDF]

				J. Butler, G. L. Chong, MMed(Anaes), R. J. Baigrie, R. Pillai, S. Westaby, and G. M. Rocker Cytokine responses to cardiopulmonary bypass with membrane and bubble oxygenation Ann. Thorac. Surg., May 1, 1992; 53(5): 833 - 838. [Abstract] [PDF]

				M. L. Myers, C. Webb, M. Moffat, D. McIver, and R. D. Maestro Activated neutrophils impair rabbit heart recovery after hypothermic global ischemia Ann. Thorac. Surg., February 1, 1992; 53(2): 247 - 252. [Abstract] [PDF]

				T. E. Mollnes, V. Videm, O. Gotze, M. Harboe, and M. Oppermann Formation of C5a during cardiopulmonary bypass: Inhibition by precoating with heparin Ann. Thorac. Surg., July 1, 1991; 52(1): 92 - 97. [Abstract] [PDF]