HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Videm, V. Articles by Svennevig, J. L. Search for Related Content PubMed PubMed Citation Articles by Videm, V. Articles by Svennevig, J. L.

The Annals of Thoracic Surgery, Vol 50, 387-391, Copyright © 1990 by The Society of Thoracic Surgeons

ARTICLES

Complement activation with bubble and membrane oxygenators in aortocoronary bypass grafting

V Videm, E Fosse, TE Mollnes, P Garred and JL Svennevig
Institute for Experimental Medical Research, Ullevaal Hospital, Oslo, Norway.

Thirty-three patients admitted for coronary bypass grafting were randomized to cardiopulmonary bypass with a bubble oxygenator (Cobe or Polystan) or a membrane oxygenator (SciMed). Plasma concentrations of C3 activation products and the terminal complement complex were measured using enzyme immunoassays. Both variables increased almost linearly after onset of cardiopulmonary bypass, with maximal concentrations at closure of the sternum. From a baseline of 7.5 to 12.0 arbitrary units (AU)/mL (medians), the concentrations of C3 activation products increased by 117.5 AU/mL (Cobe), 120.5 AU/mL (Polystan), and 213.3 AU/mL (SciMed). The increase in the membrane group was significantly higher than in the two bubble oxygenator groups (p less than 0.01). From a baseline of 0.9 to 1.3 AU/mL, the concentrations of terminal complement complex increased by 5.4 AU/mL (Cobe), 6.6 AU/mL (Polystan), and 7.7 AU/mL (SciMed) (differences not significant). The higher C3 activation caused by the membrane oxygenator may be explained by differences in flow profile and surface area in contact with blood. The study cannot confirm the general assumption that membrane oxygenators lead to lower complement activation than do bubble oxygenators.

This article has been cited by other articles:

				T. N Hoel, V. Videm, S. T Baksaas, T. E Mollnes, F. Brosstad, and J. L Svennevig Comparison of a Duraflo II-coated cardiopulmonary bypass circuit and a trillium-coated oxygenator during open-heart surgery Perfusion, May 1, 2004; 19(3): 177 - 184. [Abstract] [PDF]

				M. Flynn, S. Reddy, W. Shepherd, C. Holmes, D. Armstrong, C. Lunn, K. Khan, and S. Kendall Fast-tracking revisited: routine cardiac surgical patients need minimal intensive care Eur. J. Cardiothorac. Surg., January 1, 2004; 25(1): 116 - 122. [Abstract] [Full Text] [PDF]

				R. D. Riley, H. Sato, Z.-Q. Zhao, V. H. Thourani, J. E. Jordan, A. X. Fernandez, X.-L. Ma, D. R. Hite, D. F. Rigel, T. C. Pellas, et al. Recombinant human complement C5a receptor antagonist reduces infarct size after surgical revascularization J. Thorac. Cardiovasc. Surg., August 1, 2000; 120(2): 350 - 358. [Abstract] [Full Text] [PDF]

				M. Tofukuji, C. Metais, C. D. Collard, D. S. Morse, G. L. Stahl, D. P. Nelson, J. Li, M. Simons, and F. W. Sellke Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pig Ann. Thorac. Surg., January 1, 1999; 67(1): 112 - 119. [Abstract] [Full Text] [PDF]

				R de Vroege, P M. Rutten, C Kalkman, T A Out, P G. Jansen, L Eijsman, B J. de Mol, and C R. Wildevuur Biocompatibility of three different membrane oxygenators: effects on complement, neutrophil and monocyte activation Perfusion, December 1, 1997; 12(6): 369 - 375. [Abstract] [PDF]

				J. Svennevig, S. Tollofsrud, U. Kongsgaard, H. Noddeland, B. Mohr, M. Ozer, and T. Mollnes Complement activation during and after open-heart surgery is only marginally affected by the choice of fluid for volume replacement Perfusion, January 1, 1996; 11(4): 326 - 332. [Abstract] [PDF]